神经和血管细胞粘附分子与精神分裂谱系障碍患者的认知功能有关:一项纵向研究
Kristian Varden Gjerde1, Christoffer Bartz-Johannessen2, Else-Marie Løberg3
1NKS Olaviken Gerontopsychiatric Hospital, Erdal, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway; Division of Psychiatry, Haukeland University Hospital, Bergen, Norway; Mohn Research Center for Psychotic Disorders, Bergen, Norway.
Schizophrenia research
|February 4, 2026
概括
像N-CAD和ICAM-1这样的细胞粘附分子 (CAM) 与精神分裂症患者的认知功能有积极的关联. JAM-A水平与执行功能有负相关性,这表明CAMs影响精神分裂症认知.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 精神分裂症的发病可能涉及内皮炎症和血脑屏障 (BBB) 失调.
- 细胞粘附分子 (CAMs) 是BBB完整性和炎症的关键媒介.
- 认知功能障碍是精神分裂症的核心特征,通常在精神病症状之前.
研究的目的:
- 研究在精神分裂症谱系障碍中CAMs蛋白水平和神经认知表现之间的关系.
- 通过了解CAMs在认知缺陷中的作用来探索潜在的治疗点.
- 在BeSt InTro研究中分析CAM对各种认知领域的影响.
主要方法:
- 71名精神分裂症患者 (住院和门诊) 在多个时间点进行了评估.
- 神经心理测试包括工作记忆,处理速度,语言能力,执行功能和整体认知.
- 在血液样本中测量了CAMs (JAM-A,N-CAD,ICAM-1,VCAM-1,MADCAM,P-selectin);统计模型根据混因素进行了调整.
主要成果:
- 神经卡德林 (N-CAD) 与整体认知,工作记忆和执行功能正相关.
- 细胞间粘附分子 (ICAM) -1 与整体认知正相关.
- 交界粘附分子 (JAM-A) 与执行功能负相关.
结论:
- 在精神分裂症中,CAMs,特别是N-CAD,ICAM-1和JAM-A与认知功能有关.
- 与假设相反,大多数CAM与认知测试的关联是积极的.
- 需要进一步的研究,以阐明CAMs对精神分裂症认知的影响背后的确切机制.
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