抗精神病耐药精神分裂症的异常运动皮质可塑性:使用跨直流和磁刺激的横截面研究
Kiran Bagali1, Chithra Uppinkudru1, Harsh Pathak1
1Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, 560029, Karnataka, India.
Schizophrenia research
|February 4, 2026
概括
与健康人相比,抗精神病药物耐药性精神分裂症患者的运动皮质可塑性受损. 这种损伤在超抗性精神分裂症中更严重,这表明可塑性可能是生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经生理学 神经生理学
背景情况:
- 精神分裂症治疗耐药性是一个重大的临床挑战.
- 皮质可塑性受损是抗精神病药物耐药性的潜在机制.
- 高清超直流刺激 (HD-tDCS) 可以调节皮质可塑性.
研究的目的:
- 在抗精神病药物耐药精神分裂症 (ARS) 的HD-tDCS后使用短间隔皮质抑制 (SICI) 评估运动皮质可塑性.
- 为了比较ARS患者和健康对照者之间的可塑性变化.
- 研究克洛扎耐药性 (超耐药性精神分裂症 - URS) 和一线抗精神病药物耐药性精神分裂症之间的可塑性差异.
主要方法:
- 53名ARS患者和31名健康受试者接受了TMS-EMG.
- 在SICI测量之前和在单次阴极HD-tDCS在左侧M1区域后的多个时间点.
- 线性混合效应模型评估了SICI和Motor Evoked Potential (MEP) 在1mV的群组和时间效应.
主要成果:
- 与对照人群相比,ARS患者在HD-tDCS后的运动皮质激发性变化显著较差,且持续时间较短.
- 超耐药精神分裂症 (URS) 参与者表现出比一线抗精神病药物耐药精神分裂症患者的可塑性较差.
- 在SICI中,在HD-tDCS.40分钟后观察到一个显著的群体*时间相互作用.
结论:
- 这项研究证实ARS中运动皮质可塑性受损.
- 具有较高的症状负担和较差的功能特征的URS患者,在运动皮质可塑性中表现出最显著的损伤.
- 皮层可塑性作为精神分裂症的预测性,机械性和感知性生物标志物具有潜力.
相关概念视频
01:50Cross-Sectional Research
12.6K
In cross-sectional research, a researcher compares multiple segments of the population at the same time. If they were interested in people's dietary habits, the researcher might directly compare different groups of people by age. Instead of following a group of people for 20 years to see how their dietary habits changed from decade to decade, the researcher would study a group of 20-year-old individuals and compare them to a group of 30-year-old individuals and a group of 40-year-old...
12.6K
01:11Direct Motor Pathways
4.5K
The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
4.5K
01:24Finding Volume Using Cross-Sectional Area
73
For solids whose cross-sectional areas vary in a predictable way, volume can be determined by integrating these areas along an axis perpendicular to the slices. This approach is particularly useful for polyhedral solids, where classical geometric formulas may not be immediately applicable. A tetrahedron provides a clear example of how cross-sectional integration can be applied to a three-dimensional object with continuously changing geometry.Consider a tetrahedron with height h and a base that...
73
01:26Profile Leveling and Cross Sections
1.7K
Profile leveling and cross-sections are surveying methods used to determine and document terrain elevations for infrastructure projects such as highways, railroads, canals, and pipelines. These methods provide data for earthwork planning and alignment of proposed routes. Profile leveling involves measuring elevations along a fixed line to create a vertical terrain profile. A surveyor sets up a leveling instrument at the benchmark (BM) and records a backsight (BS) to determine the...
1.7K
01:20Motor Unit Stimulation
3.8K
When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
3.8K
01:16Spinal Cord: Cross-sectional Anatomy
4.9K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
Gray Matter and its Components
Central to the gray matter is...
4.9K