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肥胖中的宿主微生物群相互作用:免疫代谢失调调

Ning Zhihan¹, Gou Weiyu¹, Gan Luo²

¹School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Obesity reviews : an official journal of the International Association for the Study of Obesity

|February 4, 2026

概括

肠道微生物群疾病是导致肥胖的关键因素. 涉及免疫代谢的宿主微生物相互作用提供了对肥胖的洞察力.

科学领域:

微生物组研究的研究.
免疫学免疫学免疫学
代谢性疾病是一种代谢性疾病.

背景情况:

肥胖是一个主要的健康问题,具有严重的后果.
肠道微生物群失调是肥胖发展的一个重要因素.
微生物和宿主因素相互作用,影响新陈代谢和免疫过程.

研究的目的:

审查宿主微生物相互作用中的免疫代谢机制.
探索肠道微生物群在肥胖病因学中的作用.
为了阐明理解肥胖的原因的边界.

主要方法:

关于宿主微生物相互作用的文献综述.
免疫和代谢途径的分析.
综合关于肠道微生物群和肥胖的当前研究.

主要成果:

肠道微生物产生代谢物 (脂多糖,短链脂肪酸,细胞外囊泡),影响宿主免疫和代谢.
主体因素 (外体,抗微生物,干扰素系统) 破坏微生物平衡,影响新陈代谢和免疫力.
宿主和微生物群之间的双向通信显著导致肥胖.

结论:

主体-微生物相互作用,特别是免疫代谢,是肥胖症的核心.
了解这些复杂的相互作用对于新的肥胖干预措施至关重要.
进一步研究肠道微生物群在肥胖中的作用是有必要的.

关键词:

细胞外囊泡中的细胞外囊泡.我们的肠道微生物群.免疫力是一种免疫力.代谢代谢代谢代谢微生物肠大脑轴肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖

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