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认知后续与对体和对体外神经囊性结相关
Rebeca Ramírez-Bustamante1, Ana Ruth Diaz-Victoria2, Agnès Fleury3
1Neuroinflammation Unit, Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigación Biomédicas, Universidad Nacional Autónoma de México/Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez (INNN-MVS), México City, México.
神经囊硬化 (NC) 幸存者经常经历显著的认知障碍,包括痴呆和轻度认知障碍,即使在感染清除后. 这些认知缺陷需要在患者护理中进行识别和管理.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 神经科学是一个神经科学.
背景情况:
- 神经囊硬化症 (NC) 的发病率在某些地区正在下降,但全球负担和持续的神经系统的后果仍然很大.
- 在NC管理中,认知表现经常被忽视,一旦寄生虫无法检测,患者通常被认为已经治愈.
研究的目的:
- 评估有神经囊病史的患者认知后果的频率,特征和严重程度.
主要方法:
- 研究人员对105名有NC病史 (没有可活寄生虫) 的患者进行了横截面研究.
- 患者被分为对细胞NC (单个/多个化) 和治愈的对细胞外NC组.
- 使用MMSE和MoCA评估认知功能,与健康的对照组相比.
主要成果:
- 与对照组相比,有NC病史的患者表现出显著的认知障碍 (MMSE,MoCA) (p < 0.0001).
- 超体NC (18%) 与体NC (0%) 的痴呆频率较高 (p=0.001);超体NC (78%) 与超体NC (47.3%) 的轻度认知障碍较高 (p=0.003).
- 认知功能没有受到,治疗或之前的NC干预的影响;MMSE和MoCA得分与正相关 (r=0.65,p < 0.0001).
结论:
- 神经囊性结与大量的认知后果有关.
- 这些认知缺陷需要被认可并纳入全面的患者护理策略.
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