基于微循环血液动力学功能障碍的多维特征评估,用于瓦格纳0级糖尿病足患者
Yanan Zhao1, Jing Zhang1, Yangxi Li2
1School of Nursing, Capital Medical University Beijing, China.
Diabetes research and clinical practice
|February 4, 2026
概括
糖尿病足 (DF) 患者在脚部表现出微循环功能障碍,包括输液减少和自主调节受损. 脚部微循环的多维分析有效地将DF与非DF个体区分开来.
科学领域:
- 生物医学工程 生物医学工程
- 血管生物学 血管生物学
- 糖尿病学 糖尿病学
背景情况:
- 糖尿病足 (DF) 并发症显著影响患者的流动性和生活质量.
- 了解微循环异常对于早期发现和管理DF至关重要.
研究的目的:
- 在DF患者中描述足部微循环的多维血动力学异常.
- 调查微循环功能障碍与脚部压力热点 (MT1,MT5) 之间的关系.
- 开发一种基于微循环特征的区分模型来识别DF.
主要方法:
- 在286名参与者中收集了MT1和MT5的微循环信号 (157名非DF,129名DF).
- 提取了时间域,频率域,节奏性和对称性特征.
- 使用曼-惠特尼U测试,斯皮尔曼相关性,LASSO和多变量逻辑回归进行分析.
- 使用ROC-AUC和Youden指数评估模型性能.
主要成果:
- 在MT1和MT5中,DF患者的平均 perfusion 值显著降低 (p < 0.001).
- 在MT1下降的神经源和肌源频段功率表明自主调节减弱.
- 观察到节律变化 (峰值较少,间隔较长) 和双边协调受损.
- 结合MT1和MT5模型实现了最高的歧视 (ROC-AUC = 0.906).
结论:
- DF与微循环功能障碍的复杂模式有关,包括输液不良,自主功能障碍和协调改变.
- 多维微循环特征为DF风险分层提供了一种定量方法.
- 这种方法有助于表型描述与DF相关的微循环异常.
关键词:
糖尿病足患者的糖尿病足.最小绝对收缩和操作员的选择.微循环是一种微循环.足部 perfusion 输液 足部 perfusion 足部 perfusion 足部 perfusion 足部 perfusion 足部 perfusion 足部 perfusion 足部 perfusion 足部 perfusion 足部 perfusion 足部 perfusion 足部 perfusion 足部 perfusion 足部 perfusion 足部 perfusion 足部 perfusion 足部 perfusion 足部 perfusion 足部 perfusion 足部 perfusion接收器的运行特征曲线.相关概念视频
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