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Updated: Feb 6, 2026

Efficient Transfection of In vitro Transcribed mRNA in Cultured Cells Using Peptide-Poloxamine Nanoparticles
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大型和低PEG脂质纳米颗粒使强效的mRNA癌症疫苗能够有效地向树突细胞

Xiaolan Xu1, Jiahao An2, Dan Bai1

  • 1State Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

Journal of controlled release : official journal of the Controlled Release Society
|February 4, 2026
PubMed
概括

大脂质纳米颗粒 (LLNPs) 增强信使RNA (mRNA) 向树突细胞 (DC) 的传递,以改善癌症疫苗. 这种新的平台显示出卓越的直流向和强大的抗瘤作用,为下一代免疫疗法铺平了道路.

关键词:
向树突细胞的向.脂质纳米颗粒的使用方法含有PEG脂质的蛋白质含量大小调制尺寸调制在mRNA癌症疫苗的使用中.

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