用可穿戴加速度计和标准化精细运动评估量化晚年抑郁症的运动模式组成
Heng Shao1, Zhimin Mao2, Zhong Zhao3
1Department of Geriatrics, The First People's Hospital of Yunnan Province, Kunming University of Science and Technology Affiliated Hospital, Kunming, 650032, China.
Journal of affective disorders
|February 4, 2026
概括
与健康对照组 (HC) 相比,晚期抑郁症 (LLD) 患者表现出不同的精细运动执行模式. 加速度计准确地区分这些运动特征,有助于老年人的客观诊断.
科学领域:
- 老年学是一门学科.
- 神经学 神经学
- 生物医学工程 生物医学工程
背景情况:
- 晚年抑郁症 (LLD) 在老年人中在诊断和治疗方面存在独特的挑战.
- 需要客观生物标志物来补充LLD的临床评估.
- 精细运动执行通常会在神经和精神疾病中受到影响.
研究的目的:
- 描述LLD和健康对照 (HC) 的老年人之间精细运动任务的动力学差异.
- 评估机器学习模型的可行性和稳定性,以基于运动执行特征对LLD进行分类.
- 为了确定客观的,可重现的运动模式差异,表明LLD.
主要方法:
- 95名参与者 (58名LLD,37名HC) 通过Purdue Pegboard和Clock Drawing测试进行了精细运动评估.
- 在两个手腕上佩戴AX6三轴加速度计,以捕获100赫兹的动力学数据.
- 数据预处理涉及信号向量大小,主要组件分析和高斯混合物模型集群,以导出电机模式特征.
主要成果:
- 与HC相比,LLD患者在Purdue Pegboard子测试中表现明显差.
- 任务级动力学分析显示,所有任务中的"模式组成"有显著差异 (p < 0.01).
- 机器学习模型 (Lasso-logistic,XGBoost) 实现了基于运动模式的LLD检测的高分类精度 (0.89) 和AUC (0.94-0.95).
- LLD与间歇性,高峰和节奏不稳定的动态模式有关.
结论:
- 腕式加速度计与精细运动任务相结合,提供客观,可重复的"运动模式指纹".
- 这些客观措施在节奏组织和运动稳定性方面有效地将LLD与HC区分开来.
- 这种方法为老年人客观LLD评估提供了一个有希望的工具.
更多相关视频
14:55Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI
Published on: April 18, 2011
14.2K
08:51Author Spotlight: Unveiling Neural Mechanisms Through Automated Evaluation of Motor Learning and Myelin Plasticity Studies Using the Erasmus Ladder
Published on: December 15, 2023
2.1K
相关概念视频
Motor Units
62.0K
A motor unit consists of two main components: a single efferent motor neuron (i.e., a neuron that carries impulses away from the central nervous system) and all of the muscle fibers it innervates. The motor neuron may innervate multiple muscle fibers, which are single cells, but only one motor neuron innervates a single muscle fiber.
62.0K
Motor Units
8.2K
The motor unit is a fundamental component of the neuromuscular system and plays a crucial role in coordinating muscle contractions. It consists of a somatic motor neuron, which connects and controls multiple skeletal muscle fibers, forming a single functional segment. The axon of the motor neuron branches out and establishes synaptic connections known as neuromuscular junctions with individual muscle fibers within the motor unit.
Motor units come in different sizes, with smaller units...
Motor units come in different sizes, with smaller units...
8.2K
Motor Unit Stimulation
3.8K
When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
3.8K
Hierarchy of Motor Control
6.3K
The hierarchy of motor control refers to the different levels of organization and processing involved in controlling movement in the body. These levels range from higher cortical areas involved in planning and decision-making to lower spinal cord reflexes that respond automatically to external stimuli.
6.3K
Direct Motor Pathways
4.5K
The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
4.5K
Microtubule Associated Motor Proteins
10.7K
Eukaryotic cells have different motor proteins for transporting various cargo within the cell. These motor proteins differ based on the filament they associate with, the direction they move within the cell, and the type of cargo they transport. Motor proteins that associate with microtubules are known as microtubule-associated motor proteins. There are two families of microtubule-associated motor proteins —Kinesins and Dyneins. Both these proteins assist in the transport of cellular...
10.7K
