双组分 (谷物和饮料) 补充剂通过免疫调节和病原体抑制,对沙门氏菌感染产生保护作用
Seyedeh Masoomeh Hosseini1, Sara Basiri1, Seyed Shahram Shekarforoush1
1Department of Food Hygiene and Public Health, School of Veterinary Medicine, Shiraz University, Shiraz, 71441-11731, Iran.
Microbial pathogenesis
|February 4, 2026
概括
凯菲尔谷物和饮料混合物有效地对抗老鼠的沙门氏菌 Typhimurium 感染. 这种益生菌干预减少了病原体水平和炎症,为抗击沙门氏菌提供了一种新的策略.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 沙门氏菌感染对公众健康构成重大威胁,需要新的益生菌解决方案.
- ,一种发酵乳制品,显示出作为益生菌剂的希望.
研究的目的:
- 在大鼠模型中,评估麦和饮料混合物对沙门氏菌Typhimurium感染的保护作用.
- 为了研究结合开谷和饮料的协同作用,以提高益生菌的有效性.
主要方法:
- 36只老鼠被分为对照组,开 + 沙门氏菌组和仅含沙门氏菌的组.
- 凯菲尔每天服用四周,随后是沙门氏菌Typhimurium挑战.
- 评估了沙门氏菌水平,肝酶,炎症标志物和白细胞计数.
主要成果:
- 凯菲尔治疗显著降低了肝脏,脏,便和脏中的沙门氏菌水平.
- 凯菲尔减轻了感染引起的肝酶和炎症标志物 (IL-10,SAA,TNF-α) 的增加.
- 酒抑制了白细胞数量的增加,这表明炎症减少.
结论:
- 咖啡豆和饮料的联合使用作为一种强大的益生菌干预沙门氏菌.
- 这种双源益生菌减少了病原体的增殖,限制了器官损伤,并调节了免疫反应.
- 这项研究强调了开谷和饮料的协同保护作用,超过了单独的开饮料的疗效.
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