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Updated: Feb 6, 2026

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在阻塞性睡眠呼吸暂停中视网膜微血管变化的表征使用光学一致性断层扫描血管学:来自ORNET研究的数据
Clément Germanese1, Marjolaine Georges2, Philippe Bonniaud2
1Department of Ophthalmology, University Hospital, F-21000, Dijon, France.
Ophthalmology
|February 4, 2026
概括
阻塞性睡眠呼吸暂停综合征 (OSAS) 与深层毛细血管中的视网膜微血管密度降低有关. 持续的正气道压力 (CPAP) 治疗并没有随着时间的推移显著改变这些视网膜变化.
科学领域:
- 眼科医生 眼科 眼科
- 睡眠医学 睡眠医学
- 血管生物学 血管生物学
背景情况:
- 阻塞性睡眠呼吸暂停综合征 (OSAS) 是一种与全身血管并发症相关的普遍疾病.
- 视网膜微血管可以作为系统血管健康的窗口.
- 光学连贯断层扫描血管造影 (OCT-A) 允许对视网膜微血管的非侵入性可视化.
研究的目的:
- 使用OCT-A与健康对照组相比,研究OSAS患者视网膜微血管变化.
- 评估持续正气道压力 (CPAP) 治疗对OSAS患者视网膜微血管结构的影响.
主要方法:
- 前性队列研究包括162名参与者 (82名OSAS,80名对照).
- 使用OCT-A量化视网膜血管密度 (VD) 和 perfusion density (PD) 在表面和深层毛细管 (SCP, DCP),状血管区域 (FAZ) 和周毛细管区域.
- 用多变量混合效应模型进行比较,并根据相关的共变量进行调整. 在CPAP治疗后评估了长度变化.
主要成果:
- 与对照组相比,OSAS参与者在DCP中显著减少了视网膜VD和PD (分别为p=0.024和p=0.03).
- 两组之间在SCP,FAZ或周囊区域之间没有发现显著差异.
- 在CPAP启动后的随访期间,视网膜微血管参数在很大程度上保持不变,即使在调整治疗顺应后也是如此.
结论:
- OSAS与微血管变化有关,特别是在视网膜深层毛细管内.
- 在随访期间,CPAP治疗的开始并没有导致这些视网膜微血管参数的显著改善.
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