在中国的宫癌查期间检测月经血液是否存在人类乳头瘤病毒:基于人口的横截面研究
Xun Tian1, Chen Cao1, Lejing Wang1
1Department of Obstetrics and Gynecology, Academician Expert Workstation, the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
概括
迷你月经血液HPV测试显示了与临床医生采集的样本相比的诊断准确性,用于检测2/3级或更糟糕的宫内皮质瘤 (CIN2+). 这为宫癌查提供了一个有希望的替代方案.
科学领域:
- 妇科 妇科 妇科 妇科
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
背景情况:
- 宫癌查依赖于检测高风险的人类乳头瘤病毒 (HPV) 感染.
- 目前的方法通常需要临床医生收集的宫样本,这可能是侵入性的.
- 探索更少的侵入性样本类型,如月经血液,对于改善查可访问性至关重要.
研究的目的:
- 为了评估HPV测试的诊断准确性,使用通过迷你收集的自我收集的月经血液与临床医生收集的宫样本相比.
- 为了确定minipadHPV测试在检测2/3级或更严重 (CIN2+/CIN3+) 的宫内皮质瘤检测中的有效性.
主要方法:
- 一项基于人口的横截面研究,涉及中国3068名年龄在20-54岁的女性.
- HPV 检测是在小子收集的月经血液和临床医生收集的宫样本上进行的.
- 阳性HPV测试或细胞异常的参与者被转诊进行结肠镜检查和活检以确定诊断.
主要成果:
- 迷你型HPV测试显示CIN2+检测的灵敏度为94.7%,与临床医生测试 (92.1%) 相比.
- 微型测试 (89.1%) 与临床医生测试 (90.0%) 的特异性略低,但负预测值相同 (99.9%).
- 两种方法均表现出相似的积极预测值和选效率,每次CIN2+检测到可比的转诊.
结论:
- 用迷你收集的月经血液是用于宫癌查中的HPV检测的可行和准确的替代方案.
- 这种方法显示了与传统的临床医生收集的宫样本用于检测CIN2+和CIN3+的诊断性能相似的诊断性能.
- 迷你型HPV检测有潜力提高查参与度和可访问性.
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