在复发性复发性多发性硬化症中,脑缩率随年龄而异
Sezgi Kaçar1,2, David R van Nederpelt3, Julia R Jelgerhuis2
1MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Amsterdam, The Netherlands s.kacar@amsterdamumc.nl.
Journal of neurology, neurosurgery, and psychiatry
|February 4, 2026
概括
患有复发性缓解性多发性硬化症 (RRMS) 的老年人在基线时显示出更多的大脑缩,但随着时间的推移,缩的速度较慢. 在RRMS临床试验中,年龄显著影响大脑体积的变化.
科学领域:
- 神经学 神经学
- 临床试验 临床试验
- 神经成像是一种神经成像.
背景情况:
- 脑缩是复发性复发性多发性硬化症 (RRMS) 试验的关键结果.
- 慢性年龄与多发性硬化症对大脑缩的特异性影响之间的相互作用尚未得到充分理解.
- 虽然健康的衰老通常会增加缩,但多发性硬化症患者可能会呈现下降的病率.
研究的目的:
- 为了研究慢性年龄与RRMS中大脑体积变化之间的关系.
- 确定年龄如何影响临床试验参与者的脑缩率.
- 评估疾病持续时间对与年龄相关的缩模式的影响.
主要方法:
- 从4241名RRMS试验参与者 (96周随访) 的汇总数据分析.
- 分类为七个年龄组 (18-56岁).
- 多层线性混合效应回归模型检查正常化全脑体积 (NWBV),丘脑灰质体积 (NThGMV),灰质体积 (NGMV) 和白质体积在基线和随着时间的推移.
主要成果:
- 与年轻参与者相比,老年参与者基线NWBV,NGMV和NThGMV较低.
- 年龄较大的参与者在随访期间表现出明显较低的脑缩率,特别是在 thalamus.
- 这些与年龄相关的缩率差异在所有疾病持续时间小组中都是一致的.
结论:
- 较老的RRMS患者出现更大的基线缩,但随着时间的推移,其乳头缩率会降低.
- 年龄是影响RRMS脑缩进展的独立因素.
- 在设计RRMS临床试验时,必须考虑使用脑缩作为结果指标的时间年龄.
关键词:
多发性硬化 多发性硬化
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