相关实验视频

Updated: Feb 6, 2026

Expanding the Toolkit for In Vivo Imaging of Axonal Transport
09:24

Expanding the Toolkit for In Vivo Imaging of Axonal Transport

Published on: December 23, 2021

4.0K

TBK1的活动调节信号内分泌体轴突运输的方向性

David Villarroel-Campos1,2, Jose Norberto S Vargas1,2, Martin Wallace1

  • 1Department of Neuromuscular Diseases, and UCL Queen Square Motor Neuron Disease Centre, Queen Square Institute of Neurology, University College London, London, UK.

Life science alliance
|February 4, 2026
PubMed
概括

肌缩侧面硬化症 (ALS) 涉及到受损的轴突运输. 我们发现基因酶TBK1酸化Rab7,这对神经元中单向信号内体体运输至关重要,这表明TBK1功能障碍导致ALS相关的运输缺陷.

更多相关视频

Axonal Transport of Organelles in Motor Neuron Cultures using Microfluidic Chambers System10:12

Axonal Transport of Organelles in Motor Neuron Cultures using Microfluidic Chambers System

Published on: May 5, 2020

10.7K
Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

8.0K

相关概念视频

Regulated mRNA Transport02:22

Regulated mRNA Transport

In eukaryotes, transcription and translation are compartmentalized; an mRNA is first synthesized in the nucleus and then selectively transported to the cytoplasm for protein synthesis. Before transport, a pre-mRNA undergoes several steps of post-transcriptional modifications including splicing, 5' capping, and the addition of a poly-adenine tail. Various proteins bind to the pre-mRNA during these modifications. The mRNA transport takes place with the help of multiple proteins playing...
7.0K
Regulated mRNA Transport02:22

Regulated mRNA Transport

3.4K
Primary Active Transport01:47

Primary Active Transport

In contrast to passive transport, active transport involves a substance being moved through membranes in a direction against its concentration or electrochemical gradient. There are two types of active transport: primary active transport and secondary active transport. Primary active transport utilizes chemical energy from ATP to drive protein pumps that are embedded in the cell membrane. With energy from ATP, the pumps transport ions against their electrochemical gradients—a direction...
199.2K
Primary Active Transport01:29

Primary Active Transport

In contrast to passive transport, active transport involves a substance being moved through membranes in a direction against its concentration or electrochemical gradient. There are two types of active transport: primary active transport and secondary active transport. Primary active transport utilizes chemical energy from ATP to drive protein pumps embedded in the cell membrane. With energy from ATP, the pumps transport ions against their electrochemical gradients—a direction they would...
14.4K
Secondary Active Transport01:55

Secondary Active Transport

One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme “pump” embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
138.0K
Secondary Active Transport01:32

Secondary Active Transport

One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme "pump" embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
9.7K