小血管疾病与超重和肥胖的人之间的关联:使用骨化平均扩散度的峰值宽度的研究
Kang Min Park1, Jin-Hong Wi2, Bong Soo Park3
1Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
Obesity research & clinical practice
|February 4, 2026
概括
较高的体重指数 (BMI) 与大脑中早期的白质变化有关,通过骨化平均扩散率 (PSMD) 的峰值宽度检测到. 这种成像标记可能有助于识别与肥胖相关的脑微血管损伤.
科学领域:
- 神经学 神经学
- 放射学 放射学是指放射学
- 公共卫生 公共卫生
背景情况:
- 肥胖和超重是脑血管疾病的危险因素,如小血管疾病 (SVD).
- 骨化平均扩散率 (PSMD) 的峰值宽度是一种扩散张力成像标记,用于与SVD相关的白质变化.
- 身体质量指数 (BMI) 和PSMD之间的联系尚不清楚.
研究的目的:
- 调查健康成年人BMI和PSMD之间的关联.
- 确定PSMD是否可以作为肥胖相关的大脑微血管变化的成像生物标志物.
主要方法:
- 用扩散张力成像进行的大脑MRI对62名健康成年人进行了测试.
- 参与者根据世卫组织亚太地区标准分为BMI组.
- 使用统计分析,包括斯皮尔曼相关性和年龄调整的残余值,来评估BMI-PSMD关系.
主要成果:
- 在BMI和PSMD之间发现了显著的正相关性 (ρ = 0.42,p=0.0007),在年龄调整后仍然存在 (ρ = 0.38,p=0.0021).
- 超重个体 (BMI 23.0-24.9 kg/m2) 的PSMD明显高于正常体重个体 (BMI 18.5-22.9 kg/m2).
- 在超重和肥胖组 (BMI ≥23.0 kg/m2) 中观察到高PSMD.
结论:
- 这项研究确立了较高的BMI和PSMD之间的显著关联,即使在亚洲人群中超重水平.
- 体重过重与早期微观结构白质变化有关,这些变化表明SVD.
- PSMD显示出作为成像生物标志物的潜力,用于检测与肥胖相关的脑微血管损伤.
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