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超声波并不是空洞化动态的绝对安全指标
Qiang Wu1, Michael D Gray1, Cameron A B Smith1
1Botnar Research Centre, Institute of Biomedical Engineering, University of Oxford, Oxford, UK.
概括
监测聚焦超声波疗法需要了解声学排放. 这项研究发现,亚波信号是空腔的不可靠指标,因此在治疗监测中需要谨慎使用它们.
科学领域:
- 声学物理学的声学物理学
- 生物医学工程 生物医学工程
- 超声波技术的超声波技术
背景情况:
- 聚焦超声波 (FUS) 应用正在扩大,需要可靠的治疗监测.
- 声学排放提供实时监控,这对于涉及化的FUS程序至关重要.
- 目前对化声学排放指标的理解缺乏共识.
研究的目的:
- 为了研究化气泡动力学和声学排放之间的关系.
- 专门研究产生低值排放的条件.
- 评估用于监测FUS治疗的声信号的可靠性.
主要方法:
- 同时对单个微气泡进行声学测量和超高速成像.
- 使用微流体装置来控制微气泡的大小和分离.
- 在治疗相关的压力范围内调查声学排放.
主要成果:
- 对于常见的空心监测频率 (和声,次和声,宽带噪声) 没有观察到明确的值.
- 没有发现化活力和亚波排放之间有明确的关系.
- 低调信号功率明显低于宽带噪声.
结论:
- 亚信号的存在或不存在应谨慎使用,作为洞穴的指标.
- 仅仅依靠低值排放来进行监测可能是不可靠的.
- 这一发现对于FUS应用中的安全至关重要,这些应用涉及非目标化.
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