怀孕期间的SARS-CoV-2感染和早期儿童的神经发育结果
Lisa A Croen1,2, Yinge Qian3, Luke Grosvenor3
1Division of Research, Kaiser Permanente Northern California, Pleasanton, CA, USA. lisa.a.croen@kp.org.
Translational psychiatry
|February 4, 2026
概括
产前的SARS-CoV-2感染并没有增加发言或运动迟缓的风险. 然而,怀孕期间的母体COVID-19与女性儿童患自闭症谱系障碍的风险更高有关.
科学领域:
- 神经科学是一个神经科学.
- 发育儿科 发育儿科
- 流行病学 流行病学
背景情况:
- 产前接触SARS-CoV-2对儿童神经发育的影响在很大程度上是未知的.
- 鉴于怀孕期间感染的普遍性,了解这些影响至关重要.
研究的目的:
- 研究怀孕期间母亲感染SARS-CoV-2和幼儿时神经发育结果之间的关联.
- 专门检查自闭症谱系障碍 (ASD),言语/语言延迟和运动延迟的风险.
主要方法:
- 一项前性纵向队列研究,对2020年1月至2021年9月期间出生的69987名儿童进行了研究.
- 通过PCR确认的母体SARS-CoV-2感染;在2023年12月之前诊断的神经发育障碍.
- 根据社会人口统计学,临床因素和疫苗接种情况进行调整的Cox比例危险回归模型.
主要成果:
- 怀孕期间母亲的SARS-CoV-2感染与言语/语言或运动延迟的风险增加无关.
- 在女性儿童中观察到自闭症谱系障碍 (ASD) 的风险增加 (aHR=1.44,95% CI 1.05-1.97).
- 没有发现男性儿童与自闭症风险有显著关联 (aHR=1.04,95% CI 0.83-1.31).
结论:
- 产前接触SARS-CoV-2可能会增加自闭症谱系障碍的风险,特别是在女性婴儿中.
- 需要进一步的研究来证实这些性别特异性发现,并探索潜在的机制.
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