白质功能连接体的发育变化
Guozheng Feng1,2,3,4, Kexin Wang1,2,3, Yichen Wang1,2,3
1State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
Molecular psychiatry
|February 4, 2026
概括
研究人员在青少年时绘制了大脑白质功能连接体 (WMFC) 的地图,揭示了三阶段的发育模式. 这个WMFC对于理解大脑成熟和神经发育障碍至关重要.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 脑部成像 脑部成像
背景情况:
- 新出现的证据将白质 (WM) 中血液氧化水平依赖的信号与神经活动联系起来.
- 研究年轻人的WM功能进化为人们提供了关于大脑发育和疾病的见解.
研究的目的:
- 在青少年和年轻人中构建和分析白质功能连接体 (WMFC) 和结构连接体 (WMSC).
- 探索WMFC的发展轨迹及其与WMSC的关系.
- 调查WMFC的分子基础和临床相关性.
主要方法:
- 利用了407名年龄在8至22岁的参与者的多式联络成像数据.
- 构建了WM功能连接体 (WMFC) 和WM结构连接体 (WMSC).
- 分析了WM结构连接-功能连接 (SC-FC) 合及其发展变化.
主要成果:
- 在WMFC中确定了一个全球三阶段重组模式 (减少-增加-减少).
- 在WMFC中观察到初级和高级网络之间的等级发展.
- 发现WM SC-FC与年龄相结合的单调下降.
- 通过神经递质受体和转录基因表达来显著调节WMFC.
- 显示的WMFC解释了神经发育障碍的区域脆弱性,并比WMSC更好地预测认知功能.
结论:
- WMFC表现出一个独特的发育轨迹,这对于理解大脑成熟至关重要.
- WMFC在神经发育障碍和认知功能中发挥着重要作用.
- 这项研究强调了WM功能在神经科学研究中的重要性.
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