试点阶段临床试验,用于连续测量药物度的可穿戴的,基于电化学aptamer的贴片
Marsilea A Booth1,2, Murat K Erdal1, Mikel Larson1
1Nutromics Pty Ltd., Brunswick, Victoria, Australia.
Nature biotechnology
|February 4, 2026
概括
基于aptamer的可穿戴电化学传感器在贴片中提供了一种安全的,最少侵入的方法来监测万科米辛水平. 这项技术提供了高分辨率的药物度数据,提高了治疗窗口狭窄的药物的精确剂量.
科学领域:
- 生物医学工程 生物医学工程
- 药理动力学 药理动力学
- 分析化学 分析化学
背景情况:
- 治疗窗口狭窄的药物需要精确的剂量,以避免毒性并确保有效性.
- 目前的稀疏血液采样方法限制了实时的药理动力学监测.
- 可穿戴的基于aptamer的电化学传感器为连续药物监测提供了一个潜在的解决方案.
研究的目的:
- 为了评估可穿戴的基于aptamer的电化学传感器贴片的安全性和性能,用于监测万科米辛度.
- 评估使用这些贴片进行高分辨率药理动力学分析的可行性.
- 为了比较皮肤间歇性液体药物度与血度.
主要方法:
- 进行了一项试点试验,涉及六名健康的人类参与者.
- 在微针上应用了带有基于电化学aptamer传感器的可穿戴贴片.
- 在24小时内测量了皮肤间歇性液体中的万科米辛度,分辨率为5分钟.
- 间歇性液体和血度与药理动力学模型相匹配.
主要成果:
- 传感器补丁被发现是安全的,几乎没有疼痛.
- 由于传感器退化,从皮肤间歇液体中捕获了高分辨率的万科米辛度数据,长达12小时.
- 药物动力学模型揭示了分布和清除动态,而稀疏采样无法检测到.
- 在不同的身体部位和参与者中观察到一致的药物度趋势.
结论:
- 基于aptamer的可穿戴电化学传感器补丁是一种安全而有前途的技术,用于精确的药物剂量.
- 这种方法可以进行详细的药理动力学分析,超越稀疏采样的局限性.
- 进一步优化,包括无线数据传输,可以提高治疗窗口狭窄的药物的临床实用性.
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