在腹手术后,在没有PCOS的肥胖女性中,月经规律和相关因素的变化
Jinshan Zhang1,2, Min Hou3, Jiali Zhang4
1Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Obesity surgery
|February 4, 2026
概括
减肥手术显著改善了肥胖妇女的月经周期规律. 影响周期规律性的关键因素包括C-,血清费里丁和孕激素水平,腹腔镜袖胃切除显示出优异的结果.
科学领域:
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
- 腹部外科 腹部外科
背景情况:
- 肥胖经常与不规则的月经周期有关,即使没有多囊性卵巢综合征 (PCOS).
- 了解这一群体中月经不规则的特定风险因素对于有针对性的干预至关重要.
- 腹腔外科手术是对肥胖的公认治疗方法,但它对月经规律性的影响需要进一步阐明.
研究的目的:
- 在没有PCOS的肥胖女性中确定不规则月经周期的独立风险因素.
- 评估腹手术 (LSG和LRYGB) 后月经周期规律的变化.
- 探索影响月经周期规律性的因素.
主要方法:
- 对430名没有PCOS的肥胖女性进行了回顾性分析,她们接受了LSG或LRYGB.
- 倾向性得分匹配 (1:1) 和无条件后勤回归用于风险因素识别.
- 在术前和术后长达12个月的时间内收集人口统计,人体测量和实验室数据.
主要成果:
- 升高的C-和血清费里丁 (SF) 是手术前不规则周期的独立风险因素;升高的孕激素是保护因素.
- 月经不规律性从手术前的53.5%下降到手术后12个月的22.6%.
- 腹腔镜袖子胃切除术 (LSG) 与腹腔镜Roux-en-Y胃绕道术 (LRYGB) 相比,在一年内,月经规律性得到了更大的改善.
结论:
- 腹腔外科手术有效地改善了没有PCOS的肥胖女性的月经周期规律.
- C-,SF和孕激素是月经规律的显著手术前预测因素.
- 手术后的月经规律受到代谢和人体指标的动态变化的影响,LSG提供了更明显的好处.
相关概念视频
The Menstrual Cycle
3.7K
The menstrual cycle is a recurrent sequence of changes in the uterine endometrium, specifically its functional layer, the stratum functionalis. This cycle prepares the uterus for potential pregnancy. This cycle typically spans 21–35 days, averaging 28 days, and aligns with the ovarian cycle, regulated by fluctuating levels of ovarian hormones, primarily estrogen and progesterone.
The menstrual phase occurs from days 1 to 5 and involves the shedding of the stratum functionalis, as a...
The menstrual phase occurs from days 1 to 5 and involves the shedding of the stratum functionalis, as a...
3.7K
Obesity
1.3K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.3K
Hormonal Regulation of the Menstrual Cycle
1.7K
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
1.7K
Drug Dosing: Obese Patients
268
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
268
Transcription Factors
82.8K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.8K
Factors Affecting Solubility
37.2K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
37.2K


