小的唾液流作为诊断工具,用于选药物诱导的 Xerostomia 中的低唾液流
Sanjana Santhosh Kumar1, Genevieve Arany-Lao-Kan2, Xiuhui Xu1
1Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA.
BMC oral health
|February 4, 2026
概括
一个简单的纸质小唾液流 (MSF) 测试可靠地选药物诱导的口腔干燥的成年人的低唾液. 这种方法显示中等准确性,并支持临床使用来检测减少的唾液分泌.
科学领域:
- 口服药是一种口服药.
- 诊断查工具 诊断查工具
- 唾液诊断 唾液诊断 唾液诊断
背景情况:
- 药物诱导的静脉是常见的,通常导致低盐度.
- 准确的查低盐度对于及时干预至关重要.
- 当前的诊断方法在现实临床环境中可能并不总是切实可行的.
研究的目的:
- 用纸质快速测试来评估小唾液流 (MSF) 速率的诊断性能.
- 为了确定MSF是否可以可靠地查药物诱导的成年人异口症.
- 为了比较MSF的诊断准确性与未刺激的全唾液 (UWS) 作为参考标准.
主要方法:
- 一项涉及135名成年人 (45-64岁) 的横截面研究,这些成年人患有异口症和使用抗胆固醇药物.
- 用一分钟的Shrimer条纹测试测量MSF;可靠性通过三次测量进行评估.
- 非刺激的全唾液 (UWS) 流被用作参考标准;接收器运行特征 (ROC) 曲线分析了诊断性能.
主要成果:
- 无线医生表明了高的内部一致性 (克朗巴赫的α=0.94) 和相互复制的协议 (r=0.83-0.87).
- 与没有低的参与者相比,低的参与者MSF明显较低 (平均差异=2.41μL/cm2/min,p<0.001).
- 在最佳切线时,MSF显示了80.0%的灵敏度和54.5%的特异性 (AUC=0.726);多变量模型的整体AUC为0.827.
结论:
- 通过简单的,非侵入性的纸质测试来测量小唾液流 (MSF) 是一种可靠和中度准确的低唾液查工具.
- 这些发现支持MSF测试在成年人中药物诱导的异口症的临床实用性.
- 需要进一步的研究来完善诊断值,并确认更广泛的适用性.
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