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高的分层双氧化物纳米片重新编程瘤稳态,用于超声波增强的烧中介免疫疗法

Xueting Yang¹, Manman Xu², Yashuo Jiang³

¹School of Pharmacy, Shandong Provincial Engineering Research Center of Novel Pharmaceutical Excipients, Sustained and Controlled Release Preparations, Dezhou University, Dezhou, 253023, P. R. China.

Journal of nanobiotechnology

|February 4, 2026

概括

高层双化物纳米薄膜 (HE-NS) 通过产生活性氧物种 (ROS) 有效地破坏细胞平衡,并促进癌症免疫疗法. 这种超声波增强的策略触发了 pyroptosis 和免疫细胞死亡,重编程瘤微环境以改善治疗结果.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

使用氧化还原纳米酶来破坏细胞平衡并增强免疫疗法,开发有效的癌症疗法仍然是一个重大挑战.
反应性氧物种 (ROS) 在细胞信号传递中起着至关重要的作用,可以用于治疗干预.

研究的目的:

开发一种基于高的新型分层双氧化物 (LDH) 纳米板 (HE-NS) 战略,用于增强癌症治疗.
调查HE-NS在破坏细胞平衡,重塑瘤微环境 (TME) 和触发免疫疗法的pyroptosis中的潜力.

主要方法:

高层双氧化物 (LDH) 纳米片 (HE-NS) 的制造.
评估HE-NS多酶催化活性,特别是过氧化酶类 (POD) 活性,有或没有超声波 (US) 照射.
密度函数理论 (DFT) 计算,以了解HE-NS中的Fe活性位点的电子结构调制.
在体外和体内研究评估HE-NS诱导的热,免疫细胞死亡 (ICD),TME重编程和整体治疗疗效.

主要成果:

与低和中等的LDH相比,HE-NS表现出优越的多酶催化活性,并通过超声波进一步增强.
DFT的计算显示,HE-NS中的多元环境优化调节Fe活性位点,降低POD类活动的能量障碍.
HE-NS显著诱导热和ICD,导致免疫抑制TME的重编程.
超声波增强的HE-NS在体外和体内癌症模型中都显示出显著的治疗效果.

结论:

拟议的高层双氧化物 (LDH) 纳米板战略为开发先进的癌症疗法提供了一个有前途的方法.
使用HE-NS的超声波增强型热中介免疫疗法有效地破坏细胞平衡,并重新编程瘤微环境.
这种新的策略具有显著的潜力,可以提高癌症治疗的疗效,并引起自适应性免疫反应.

关键词:

Fe是活性部位.高层的双氧化物高层.免疫治疗是一种免疫疗法.热性灭症是什么?

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