成年人有氧运动和血管内皮生长因子 (VEGF) 度之间的关联:随机对照试验的系统审查和元分析
Amir Hossein Zanganeh1, Reza Ghorbani Khosroshahi1, Reza Amiri Khosroshahi2
1Department of exercise physiology, faculty ofsport sciences and health, University of Tehran, Tehran, Iran.
BMC sports science, medicine & rehabilitation
|February 4, 2026
概括
在成年人中,有氧运动不会显著改变血管内皮生长因子 (VEGF) 水平. 然而,短期的运动干预措施可能会导致VEGF的减少,这需要进一步调查.
科学领域:
- 运动生理学 运动生理学
- 分子生物学分子生物学
- 心血管健康的心血管健康
背景情况:
- 血管内皮生长因子 (VEGF) 在血管生成和血管功能中起着至关重要的作用.
- 以前对有氧运动对VEGF水平的影响的研究已经产生了不一致的结果.
- 了解这些影响对于优化血管健康的运动干预措施至关重要.
研究的目的:
- 系统地审查和元分析有氧运动对成年人循环VEGF水平的影响.
- 解决现有的随机对照试验 (RCT) 中观察到的差异.
主要方法:
- 在主要的科学数据库 (ISI Web of Science,PubMed/MEDLINE,Scopus) 进行了全面的文献搜索,截至2025年5月.
- 13个符合条件的RCT被纳入随机效应元分析.
- 根据运动强度,持续时间和生物样本类型 (血清与血) 进行了子组分析.
主要成果:
- 整体元分析发现有氧运动对循环VEGF水平没有统计学上显著的影响 (SMD: -0.075; p=0.390).
- 在干预持续时间为8周或更短的研究中,观察到VEGF水平下降的趋势.
- 证据的确定性被评为非常低.
结论:
- 有氧运动似乎对成年人循环中的VEGF水平没有显著的整体影响.
- 短期有氧运动干预可能与VEGF的减少有关.
- 需要进一步进行高质量的RCT来确认这些发现并阐明潜在的机制.
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