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甲状腺功能过高和先天缺陷:母亲甲状腺功能和甲状腺自身抗体阳性的作用
Stine Linding Andersen1,2, Nanna Maria Uldall Torp1,2, Peter Vestergaard2,3,4
1Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark.
The Journal of clinical endocrinology and metabolism
|February 5, 2026
概括
怀孕早期母亲的甲状腺功能没有显示出与出生缺陷的联系. 然而,母亲的甲状腺刺激抗体可能与增加的风险有关,这需要进一步研究.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 儿科 儿科 儿科
背景情况:
- 孕产妇甲状腺功能障碍与出生缺陷有关,但甲状腺功能和自身免疫的具体作用尚不清楚.
- 了解这些关联对于产前护理和风险评估至关重要.
研究的目的:
- 研究母亲甲状腺功能,甲状腺自身抗体和后代出生缺陷的发生之间的关系.
- 为了澄清早期怀孕期间甲状腺健康对胎儿发育的影响.
主要方法:
- 一项回顾性队列研究,涉及20399名没有甲状腺疾病的孕妇.
- 对甲状腺刺激激素 (TSH),自由甲状腺素 (fT4) 和各种甲状腺自身抗体 (TPO-Ab,Tg-Ab,Trab,TSI) 的母亲血液样本的分析.
- 从医院诊断中检索出出生缺陷数据.
主要成果:
- 在有出生缺陷和没有出生缺陷的儿童之间,没有观察到母亲TSH或ft4水平的显著差异.
- 在具有或没有甲状腺过氧化酶抗体 (TPO-Ab) 或甲状腺球蛋白抗体 (Tg-Ab) 的母亲中,出生缺陷的患病率相似.
- 在母亲对TSH受体抗体 (TRAb) 或甲状腺刺激免疫球蛋白 (TSI) 呈阳性的孩子中,发现出生缺陷的更高患病率 (9.5%).
结论:
- 在怀孕早期,母亲的甲状腺功能与出生缺陷的风险增加无关.
- 孕产妇甲状腺刺激抗体 (TRAb/TSI) 可能与更高的出生缺陷风险有关,需要进一步调查.
- 这些发现有助于了解怀孕期间的甲状腺自身免疫性及其对婴儿健康的潜在影响.
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