在患有阻塞性睡眠呼吸暂停的患者中,过度白天嗜睡,认知障碍和大脑变化之间的联系
Ying Li1,2, Shiwei Lin1, Hongyue Wei1
1Department of Radiology, Shenzhen University, Shenzhen, China.
Journal of magnetic resonance imaging : JMRI
|February 5, 2026
概括
在阻塞性睡眠呼吸暂停 (OSA) 中,过度的白天嗜睡 (EDS) 与认知缺陷和改变的大脑网络有关. 具体来说,中额头回形和下额头叶片中的异常网络拓可能会调解这种关系.
科学领域:
- 神经成像是一种神经成像.
- 睡眠医学 睡眠医学
- 认知神经科学 认知神经科学
背景情况:
- 过度的白天嗜睡 (EDS) 对阻塞性睡眠呼吸暂停 (OSA) 患者的生活质量和认知有显著影响.
- 在OSA中EDS的潜在神经病理机制在很大程度上是未知的.
研究的目的:
- 在OSA患者中调查EDS,认知缺陷和大脑变化之间的关联.
- 探索大脑网络拓学在EDS和认知障碍之间的关系中的潜在调解作用.
主要方法:
- 一项前性研究涉及102名OSA患者和86名健康对照 (HC).
- 采用多参数MRI,包括沿周脉空间 (DTI-ALPS) 进行扩散张力成像和网络拓分析.
- 使用一系列神经心理测试和EDS与爱普沃思睡眠度量表评估认知表现.
主要成果:
- 与HC相比,OSA患者的认知表现较差,DTI-ALPS指数降低,网络拓异常.
- EDS与认知障碍,较低的DTI-ALPS指数和改变的网络拓学有显著的相关性.
- 双边中前回 (MFG) 和左下叶 (IPL) 的异常网络拓显示了EDS和认知缺陷之间的潜在调解效应.
结论:
- 在OSA患者中,认知,DTI-ALPS指数和网络拓都受到影响.
- 特定大脑区域 (双边MFG和左IPL) 的异常网络拓可能会调解EDS对OSA认知功能的有害影响.
相关概念视频
Sleep Apnea
581
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
581
Cognitive Dissonance
37.5K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
37.5K
Insufficient Sleep and Sleep Deprivation
942
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
942
Excess Pressure Inside a Drop and a Bubble
3.5K
The shape of a small drop of liquid can be considered spherical, neglecting the effect of gravity. This drop can further be considered as two equal hemispherical drops put together due to surface tension. The forces acting on the spherical drop are due to the pressure of the liquid inside the drop, the pressure due to air outside the drop, and the force due to the surface tension acting on the two hemispherical drops.
3.5K
Alterations in Respiration II
1.8K
There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
1.8K
Altered States of Awareness
1.1K
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
1.1K


