呈现与高血压前相关的非胰岛素抗胰岛素指数:系统性审查和元分析
Maryam Farahmand1, Sima Nazarpour2, Hanieh Malmir3
1Reproductive Endocrinology Research Center, Research Institute for Endocrine Molecular Biology, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Clinical and experimental hypertension (New York, N.Y. : 1993)
|February 5, 2026
概括
基于非胰岛素的胰岛素抵抗指数,如TyG-BMI和TyG,与高血压前期 (HTN前期) 的几率增加有关. 这些简单的工具可能有助于早期的HTN前检测,但需要进一步的研究来确认因果关系.
科学领域:
- 心脏病学 心脏病学
- 代谢健康 代谢健康
- 流行病学 流行病学
背景情况:
- 早期发现高血压前期 (HTN前期) 对于预防心血管疾病至关重要.
- 对于早期的HTN前检测,需要可靠,简单和具有成本效益的工具.
- 基于非胰岛素的指数是HTN前风险评估的潜在标志物.
研究的目的:
- 系统地审查和元分析高血压前风险与非胰岛素抗胰岛素指数之间的关联.
- 评估这些指数在识别有高血压前风险的个人的有用性.
主要方法:
- 在PubMed,Web of Science和Scopus进行了全面的文献搜索,截至2025年1月.
- 包含的研究是横截面的,调查了HTN前和胰岛素抵抗 (IR) 指数之间的关系.
- 随机效应模型被用于元分析,计算几率比率 (ORs) 和诊断几率比率 (DORs).
主要成果:
- 包括15项研究,其中14项为分析做出了贡献.
- 一些IR指数,包括TyG-BMI,TyG-WC,TG/HDL-C,METS-IR和TyG,与HTN前的几率增加显著相关 (P<0.05).
- 对TyG和TyG-BMI的DOR分别为2.67和3.45,表明了良好的诊断能力.
结论:
- 非胰岛素基础的IR指数与HTN前的更高风险有关.
- 这些指数可以作为早期HTN前检测和预防的成本效益高的工具.
- 由于横截面设计,无法推断因果关系;建议进行前性研究.
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