波利贡 (Polygonum cognatum) 提取物:多目标抗炎,抗糖尿病和表观遗传调节特性
Serhat Karaman1, Yakup Budak2, Elif Aktürk Bozdemir3
1Faculty of Medicine, Department of Emergency Medicine, Tokat Gaziosmanpasa University, Tokat, Turkiye.
ChemistryOpen
|February 5, 2026
概括
马迪马克 (Polygonum cognatum) 具有强大的抗氧化,抗炎,抗糖尿病和抗微生物活性,同时抑制了新型的基因素脱乙酶 (HDAC). 这项研究强调了其作为各种疾病的多目标治疗剂的潜力.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 药用植物 药用植物
背景情况:
- 传统上在土耳其用于药用目的的多角 (Polygonum cognatum) (马迪马克).
- 地理来源和采集时间显著影响药用植物的植物化学特征.
- 之前对P. cognatum的研究尚未全面描述其特定区域和生长阶段的植物化学物质和多目标生物活性.
研究的目的:
- 在植物生长阶段对来自中部黑海地区 (Tokat) 的P. cognatum进行全面的植物化学表征.
- 评估P. cognatum提取物的多目标生物活性,包括抗氧化,抗炎,抗糖尿病,抗微生物和素脱乙酶 (HDAC) 抑制作用.
- 确定负责观察到的生物活性的关键化合物,并探索潜在的治疗应用.
主要方法:
- 使用不同极性的溶剂 (,乙醇,水) 提取P. cognatum.
- 使用先进分析技术进行植物化学分析:液体染色学-双重质谱学 (LC-MS/MS),高性能液体染色学-二极管阵列探测器 (HPLC-DAD) 和气体染色学-质谱学 (GC-MS).
- 评估生物活性:抗氧化剂 (DPPH测定),抗炎 (COX-1/COX-2抑制),抗糖尿病 (α-氨酶和α-葡萄糖酶抑制),抗微生物 (MIC测定) 和HDAC抑制测定. 进行了分子对接研究,以与实验数据相关联结合亲和关系. 用CC50试验评估了细胞毒性.
主要成果:
- 鉴定了28种化合物,其中乙醇提取物表现出最高的多样性 (24种化合物) 和总含量.
- 在P. cognatum中首次发现了新型化合物isoquercetin-3-O-rhamnoside,apigenin-7-O-glucoside和luteolin-4'-O-glucoside.
- 乙醇提取物表现出强大的抗氧化剂,选择性抗炎药物 (COX-2优先抑制),显著的抗糖尿病和抗微生物活性. 值得注意的是,P. cognatum首次表现出显著的胰岛素脱乙酶 (HDAC) 抑制活性,这表明了表观遗传调制潜力. 关键化合物如奎尔塞丁,鲁丁,酸和凯姆菲罗尔被确定为这些活动的主要贡献者. 细胞毒性评估显示了有利的安全性 (CC50>500μg/mL).
结论:
- P. cognatum,特别是来自中部黑海地区的乙醇提取物,富含化合物,具有显著的多目标生物活动.
- 这种植物表现出新型的基因素脱乙酶 (HDAC) 抑制性质,这表明在表观遗传相关疗法中的潜力.
- 这些发现支持P. cognatum作为炎症,代谢和表观遗传疾病的有前途的治疗剂的发展.
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