母亲运动通过A-酶定蛋白150基因 (Akap5) 表观遗传修饰改善高血压后代的血管功能
Fang Qiu1,2,3, Yanyan Zhang1,2,4, Meiling Shan1
1Department of Exercise Physiology, Beijing Sport University, Beijing, China.
British journal of pharmacology
|February 5, 2026
概括
母亲运动通过降低血压和血管功能障碍,改善后代的心血管健康. 产前运动在表观遗传上修改了AKAP150基因,提供了针对遗传性高血压的策略.
科学领域:
- 心血管生理学心血管生理学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 发展生物学 发展生物学
背景情况:
- 母亲的运动有益于后代的心血管健康,但机制尚不清楚.
- 在高血压中,A-酶定蛋白150 (AKAP150) 调节血管度.
- 这项研究调查了由母体运动引起的AKAP150基因表观遗传修饰.
研究的目的:
- 揭示AKAP150基因的表观遗传修饰如何介导孕产妇的运动效益.
- 了解产前运动对高血压患者后代血管功能的影响.
主要方法:
- 使用自发高血压大鼠 (SHRs) 和AKAP150敲入小鼠.
- 在后代中枢动脉中评估了血管功能,基因表达和基因乙化.
- 分析了AKAP150-CaV1.2关联和AMPK/SIRT1通路的激活.
主要成果:
- 母亲运动降低了男性后代的血压和CaV1.2通道功能.
- 运动降低了AKAP150-CaV1.2协会和H3K9ac在Akap5促销器中的作用.
- 母亲的运动激活了AMPK/SIRT1,减少了高血压后代的AKAP150表达.
结论:
- 母亲运动通过AMPK/SIRT1.1通过Akap5促进体脱乙烯化 (H3K9ac) 改善后代的血管功能.
- 产前运动可以防止高血压的代际传播.
- 这突显了一个新的表观遗传机制,它将母亲的生活方式与后代的心血管健康联系起来.
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