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而不是FBXO7,在调节MPP+诱导的mtUPR中起着至关重要的作用

Dongni Wen1,2,3, Yunjing Li1,2,4, Lina Chen1,2,4

  • 1Department of Neurology, Fujian Medical University Union Hospital, Fuzhou 350000, China.

ACS chemical neuroscience
|February 5, 2026
PubMed
概括

在帕金森病 (PD) 模型中,CHCHD2,而不是FBXO7,对线粒体未折叠蛋白反应 (mtUPR) 至关重要. CHCHD2通过JNK和AKT通路调节线粒体蛋白质稳态,为早期PD提供潜在的治疗点.

关键词:
CHCHD2是指CHCHD2的两个部分.在FBXO7中,FBXO7是帕金森病是帕金森氏症的一种疾病.mtUPRUPR 的时间.

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