扩散阶段小细胞肺癌的长期存活率:关于干预性支气管镜和全身免疫治疗的整合的病例报告
Ganxiu Deng1,2, Shixuan Yan1, Victor Bwembya1
1Department of Respiratory and Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Frontiers in oncology
|February 5, 2026
概括
这项案例研究表明,将支气管镜干预与化疗和免疫疗法结合起来,可以为患有呼吸道阻塞的扩散阶段小细胞肺癌 (SCLC) 患者带来长期生存.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 免疫治疗是一种免疫疗法.
背景情况:
- 小细胞肺癌 (SCLC) 是具有不良预后的侵袭性,特别是广泛阶段的SCLC (ES-SCLC).
- 免疫检查点抑制剂 (ICI) 提供适度的生存益处,但长期控制是罕见的.
- 中央气道阻塞 (CAO) 复杂化了先进的SCLC,导致呼吸衰竭和治疗延迟.
研究的目的:
- 报告一个ES-SCLC病例与 CAO 通过综合治疗进行管理.
- 突出支气管镜干预在实现全身治疗中的作用.
- 为了证明长期控制疾病和长期存活的潜力.
主要方法:
- 一名65岁的男性患有ES-SCLC和CAO,经历了多次支气管镜干预 (去体积,支架,切除).
- 系统疗法包括乙化疗,塞普卢利马布 (抗PD-1抑制剂) 和维护性免疫疗法.
- 循环的炎症性细胞因子被监测在剥离后.
主要成果:
- 支气管镜干预恢复了气道的通透性,允许恢复全身治疗.
- 患者实现了持续的部分缓解,并保持了呼吸道功能.
- 稳定疾病的五年生存期在没有严重不良事件的情况下实现.
结论:
- 将支气管镜局部干预与全身疗法相结合,可以在ES-SCLC中实现持续的疾病控制.
- 这种多模式的方法可以改善选择患者的长期生存结果.
- 系统性免疫激活是由细胞因子升高后的消去建议.
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