新兴的微创激光和基于光的治疗质母细胞瘤:一个系统的审查
José Geraldo Medeiros Netto1, Lizen Clare André Moreira1, Rafaella Mafezoni1
1Department of Neurosurgery, Antônio Pedro University Hospital, Federal Fluminense University, Niterói, Brazil.
Frontiers in oncology
|February 5, 2026
概括
激光间歇性热疗法 (LITT) 和光动力学疗法 (PDT) 为质母细胞瘤提供安全,有效的最小侵入性选择,改善了部分患者的生存率. LITT对深层瘤有好处,而PDT则有助于切割后的恢复.
科学领域:
- 神经瘤学神经瘤学
- 最少侵入性的神经外科手术
- 瘤治疗方法 瘤治疗方法
背景情况:
- 质母细胞瘤是一种高度侵略性的脑瘤,对深层或雄辩区域瘤的治疗选择有限.
- 像手术,放射和化疗这样的标准治疗方法都有局限性.
- 微创替代方案如激光间歇热疗法 (LITT) 和光动力疗法 (PDT) 正在出现.
研究的目的:
- 系统地审查LITT和PDT在质母细胞瘤管理中的安全性和有效性.
- 为了比较LITT和PDT在质母细胞瘤治疗中的临床作用和结果.
- 确定患者和瘤特征,预测这些疗法的成功结果.
主要方法:
- 按照PRISMA 2020指南进行系统审查.
- 使用纽卡斯尔-太华尺度,ROBINS-I和ROB 2工具进行质量评估.
- 从11项纳入研究中提取了瘤特征,存活率,生活质量,治疗反应和并发症的数据.
主要成果:
- 对于复发性质母细胞瘤,LITT的安全性和有效性被证明是高达65%的12个月存活率,特别是在小型深层瘤中.
- 与总体切除结合的PDT减少了术后和改善了生存率,但增加了远程复发率.
- 包括的研究涉及16-86岁的患者,数据来自1468个最初识别的记录.
结论:
- LITT和PDT是质母细胞瘤的有希望的辅助疗法,可改善选择患者的生存率和减少并发症.
- 对于深层或不可切除的瘤来说,LITT特别有益,而PDT则提高了切除后的结果.
- 进一步的大规模随机试验是必要的,以优化方案,完善患者选择,并探索组合疗法.
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