在安米诺双酸输液后,急性轨道炎症综合征和视力丧失
Nicholas R Levergood1, Valerie Purvin1,2
1Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Neuro-ophthalmology (Aeolus Press)
|February 5, 2026
概括
氨基双酸盐 (AP) 可以引起轨道炎症. 一名接受佐莱德罗纳特治疗的患者因视神经炎症而视力丧失,突出显示了AP治疗的罕见但严重并发症.
科学领域:
- 眼科医生 眼科 眼科
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 氨基双酸盐 (AP) 抑制骨质再吸收,治疗骨质疏松症和帕杰特病.
- 系统性和轨道性炎症是已知的AP药物的副作用,特别是静脉注射的佐莱德酸盐.
研究的目的:
- 报告一种严重的视力丧失病例,其次是与氨基双酸相关的轨道炎症.
- 讨论这种罕见并发症的潜在机制和临床表现.
主要方法:
- 一个案例介绍,一名62岁的男性在注射佐列德酸盐后出现了轨道炎症和视力丧失.
- 关于与AP相关的轨道炎症和视神经干扰的现有文献的审查.
主要成果:
- 患者出现了类似流感的症状,右眼疼痛,随后视力丧失,白色盘.
- 尽管接受了高剂量类固醇治疗,但视力没有恢复,这表明缺血机制影响光盘血管系统.
结论:
- 这一案例扩大了已知的aminobisphosphonate相关的轨道炎症的范围.
- 视力不佳的结果可能与之前的疫苗接种或影响视神经的缺血事件有关.
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