显著的视野缺陷 持续尽管优秀的视觉敏度 后视神经炎 在 髓-寡 dendrocyte 葡萄糖蛋白相关疾病 持续
Saif Huda1, Aviv Fineberg2,3, Chiara Rocchi1
1Department of Neurology, The Walton Centre NHS Foundation Trust, Liverpool, UK.
Neuro-ophthalmology (Aeolus Press)
|February 5, 2026
概括
髓寡干细胞糖蛋白抗体相关疾病 (MOGAD) 可以导致视神经炎 (ON),导致视力丧失. 虽然视力敏度通常会恢复,但视野显示MOGAD-ON患者的视力缺陷持续,尽管治疗.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 免疫学 免疫学 免疫学
背景情况:
- 髓寡干细胞糖蛋白抗体相关疾病 (MOGAD) 是一种罕见的自身免疫性疾病,影响中枢神经系统.
- 视神经炎 (ON) 是MOGAD在成年人中常见的表现,可能导致严重的视敏度 (VA) 和视野 (VF) 缺陷.
- 虽然VA通常会随着治疗而改善,但MOGAD-ON的长期VF结果仍然不太清楚.
研究的目的:
- 分析治疗后患有MOGAD相关视神经炎 (MOGAD-ON) 的成年患者的视野 (VF) 缺陷和恢复模式.
- 为了比较MOGAD-ON患者的视敏度 (VA) 与视野 (VF) 的恢复.
- 确定影响VF恢复的因素,并描述持续的VF缺陷.
主要方法:
- 进行了对MOGAD-ON患者的多中心,国际,回顾性审查.
- 视野 (VFs) 在呈现时和至少在治疗后3个月,在复发之前被评估.
- 使用平均偏差 (MD) 来分级VF严重程度,并由盲目神经眼科医生分析特定的缺陷模式.
主要成果:
- 分析了28名MOGAD-ON患者的39只眼睛 (平均年龄为39.68岁).
- 平均平均偏差 (MD) 从呈现时的 -14.18 dB 改善到随访时的 -3.02 dB.
- 尽管VA恢复到6/6,但在随访时,46%的眼睛有永久的VF缺陷 (MD<-2dB),其中41%显示出可识别的VF模式.
结论:
- 与MOGAD-ON患者的视力敏度相比,视野恢复较差,其中很大一部分患者经历了持续的缺陷.
- 即使VA恢复良好,也可能出现持久的VF缺陷,这凸显了MOGAD-ON中全面视觉评估的重要性.
- 高度VF缺陷不应该排除MOGAD-ON,即使在之前有视神经病变和盘的情况下也是如此.
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