激活的部分血栓塑时间和孕妇的败血症休克之间的关联:一个回顾性队列研究
Shengjia Zheng1, Dunjin Chen1,2, Yuanmei Gao1
1Department of Respiratory and Critical Care Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Frontiers in medicine
|February 5, 2026
概括
孕产妇的败血症和败血性休克风险与激活的部分血栓形成时间 (APTT) 水平有关. 非常高和非常低的APTT值都表明风险增加,这表明APTT监测有助于评估产科败血症的严重程度.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 孕产妇败血症是一种具有高死亡率的临界产科并发症.
- 败血性休克是败血症的严重表现,凝血病是一个标志.
- 激活的部分血栓形成时间 (APTT) 和母亲的败血症休克之间的特定关系需要澄清.
研究的目的:
- 调查入院激活部分血栓形成时间 (APTT) 水平与感染孕妇感染败血症休克风险之间的关联.
- 确定APTT是否可以作为产科患者感染性休克的预测标记.
主要方法:
- 从2017年1月到2023年3月,对1631名感染感染的孕妇进行了回顾性分析.
- 根据入院APTT,患者被分为三组:<28秒,28-42秒和>42秒.
- 进行了统计分析,包括多变量调整和值分析,以评估APTT和败血症休克发生率之间的关系.
主要成果:
- 在APTT和败血症休克风险之间观察到U形关系.
- 与参考组 (11.8%) 相比,APTT水平>42s与败血症休克发生率显著增加 (57.9%) 相关.
- APTT<28s也表明风险增加 (调整后OR1.5),每增加1秒的APTT与震荡风险上升8.7%相关.
结论:
- 延长和缩短激活部分血栓形成时间 (APTT) 都与产科患者感染性休克风险的增加有关.
- 在产科败血症的情况下,APTT监测可能是风险分层和早期干预的宝贵工具.
- 确定关键的APTT值可以帮助管理孕产妇的败血症并改善患者的治疗结果.
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