竞争的内源性RNA网络揭示了长非编码RNA作为胃癌潜在的预后生物标志物:系统性审查和元分析
Sadra Salehi-Mazandarani1, Mohammad Hossein Donyavi2,3, Amirhossein Vedaei4
1Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran.
Advanced biomedical research
|February 5, 2026
概括
本系统性审查确定了长非编码RNA (lncRNAs) 作为胃癌 (GC) 的预后生物标志物. lncRNA CCDC144NL-AS1在GC患者中显示出显著的预后价值,突出了其潜在的临床应用.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物信息学是一种生物信息学.
背景情况:
- 胃癌 (GC) 构成了全球重大健康负担.
- 竞争的内源RNA (ceRNA) 网络涉及长非编码RNA (lncRNAs) 越来越多地被认为是其在GC预后中的作用.
- 在GC中缺乏对lncRNAs作为ceRNA的全面系统审查和元分析.
研究的目的:
- 在胃癌 (GC) 中系统地审查和元分析研究 lncRNAs作为竞争性内源性RNA (ceRNA) 生物标记物的研究.
- 根据现有文献,识别和评估GC中的lncRNAs的预后意义.
主要方法:
- 在多个数据库 (Web of Science,Embase,PubMed,Scopus,ProQuest,Google Scholar) 进行了系统的搜索,直到2024年9月20日.
- 包含了报告IncRNAs作为GC中的预后生物标志物的合格研究.
- 对高度报告的 lncRNAs 进行了元分析,以评估其预后值,包括敏感性分析和出版偏差评估.
主要成果:
- 该审查包括56项研究,评估了350个独特的lncRNA与GC患者的整体存活时间的关联.
- 28项研究有资格进行元分析.
- 四个lncRNAs (ADAMTS9-AS2,AL391152.1,CCDC144NL-AS1和PVT1) 被确定为最经常报告的预后生物标志物. 后分析证实了CCD144NL-AS1的预后效果 (HR = 1.577,95% CI: 1.382-1.801).
结论:
- 通过 ceRNA 网络研究确定的 lncRNA CCDC144NL-AS1 是一个有前途的胃癌预后生物标志物.
- 需要进行进一步的研究,以充分阐明CCDC144NL-AS1在GC病变发生过程中的功能性作用.
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