与肥胖相关的多囊卵巢综合征的传统草药:一个元分析和数据挖掘研究
Lei Tang1,2, Haijuan Liu3, Ying Pang4
1Beijing University of Chinese Medicine, Beijing, China.
Frontiers in pharmacology
|February 5, 2026
概括
传统草药 (THM) 在与常规疗法一起使用时,显著改善与肥胖相关的PCOS结果. 数据挖掘确定了关键的草药组合,表明THM.
科学领域:
- 综合医学是一个整体的医学.
- 生殖内分泌学 生殖内分泌学
- 药理学是指药理学,即药理学是指药理学.
背景情况:
- 与肥胖相关的多囊性卵巢综合征 (PCOS) 提出了复杂的临床,代谢和生殖挑战.
- 对于PCOS的传统治疗方法往往具有局限性和副作用.
- 传统草药 (THM) 越来越多地被作为辅助疗法探索.
研究的目的:
- 系统地评估THM作为肥胖相关PCOS的辅助疗法的临床疗效.
- 通过证据综合和数据挖掘,用于PCOS的THM中识别核心植物药物组合.
主要方法:
- 72项随机对照试验 (RCT) 的系统审查和元分析,涉及5308名患者.
- 数据挖掘使用阿普里奥里算法来识别核心植物药物组合.
- 使用Cochrane ROB 2.0和GRADE框架评估的偏见风险和证据确定性.
主要成果:
- THM与传统治疗相结合,显著改善了临床疗效 (OR=3.73) 和怀孕率 (OR=3.03).
- 在HOMA-IR (SMD=-0.81),BMI (SMD=-0.95),总 (SMD=-0.90) 和LH/FSH比率 (SMD=-0.88) 中观察到显著改善.
- 鉴定出Poria cocos,Citrus reticulata,Atractylodes lancea和Cyperus rotundus作为核心植物组合的植物.
结论:
- 对于与肥胖相关的PCOS来说,THM显示出优于单独使用传统治疗的优势.
- 确定了核心植物组合,需要进一步调查.
- 需要更多大规模,严格设计的RCT来证实研究结果.
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