通过母乳接触到非常低的埃纳拉普利尔和埃纳拉普利拉特:来自ConcePTION项目案例报告
Emily Jacobs1, Michael Ceulemans2,3,4, Nina Nauwelaerts5,6
1Faculty of Medicine, KU Leuven, Leuven, Belgium.
Frontiers in pharmacology
|February 5, 2026
概括
这项研究发现,埃纳拉普利尔和埃纳拉普利拉特在母乳中的转移很小,这表明母乳养婴儿的风险很低. 这些发现可以帮助制定有关母乳养的临床决策,同时接受埃纳拉普利治疗.
科学领域:
- 药理学 药理学是指药理学的学科.
- 新生儿健康 新生儿健康
- 孕产妇健康 孕产妇健康
背景情况:
- 关于母亲药物治疗的安全性数据有限,阻碍了母乳养决定.
- 之前的研究报告了婴儿对埃纳拉普利的理论暴露,但没有实际的血度.
研究的目的:
- 量化母乳中埃纳拉普利尔和埃纳拉普利拉特的含量.
- 为了估计婴儿暴露和血度.
- 为了评估母乳养的安全性,而母亲正在以纳拉普利治疗.
主要方法:
- 一位服用埃纳拉普利尔 (每天5毫克) 的母乳养母亲提供了牛奶和血液样本.
- 液体染色学与双重质谱学被用于分析.
- 计算了牛奶与血 (M/P) 的比率和相对婴儿剂量 (RID).
主要成果:
- 在牛奶中检测到低度的埃纳拉普利尔 (0.01-1.22 ng/mL) 和埃纳拉普利拉特 (0.32-0.77 ng/mL).
- 估计的每日婴儿剂量与低RID (0.073%-0.097%) 相对应.
- 婴儿血两种药物的度都低于量化的极限.
结论:
- 埃纳拉普利尔和埃纳拉普利拉特显示最小的转移到母乳中.
- 哺乳期婴儿暴露于母乳内拉普利的可能面临低风险.
- 这些发现支持针对母乳养母亲服用埃纳拉普利的最新临床指南.
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