药物诱导的免疫性血小板缺血 继发于三甲-硫甲醇
Christopher Cimperman1,2, Elysha Whitesel2,3, Amy Ray2,4
1Department of Medicine, Division of Palliative Care, MetroHealth Medical Center, Cleveland, Ohio, USA, metrohealth.org.
Case reports in infectious diseases
|February 5, 2026
概括
甲-硫法可导致严重的血小板缺血,血小板的危险下降,特别是在艾滋病患者. 这一案例显示了这种药物组合在免疫受损个体中的关键风险.
科学领域:
- 内部医学 内部医学
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
背景情况:
- 获得性免疫缺陷综合征 (AIDS) 损害了免疫系统,增加了对机会性感染和药物不良反应的易感性.
- 甲-硫甲是一种常见的抗生素,用于预防和治疗艾滋病患者的感染.
- 药物诱导免疫血小板减少 (DITP) 是一种罕见但严重的不良反应,其特征是抗体介导的血小板破坏.
研究的目的:
- 在艾滋病患者中报告与trimethoprim-sulfamethoxazole相关的严重血小板缩的致命病例.
- 突出DITP在免疫受损个体中的诊断和管理挑战.
- 为了强调三甲胺-硫甲醇在这个患者群体中的潜在风险.
主要方法:
- 一个55岁的艾滋病患者的病例报告.
- 在trimethoprim-sulfamethoxazole开始使用后,临床观察严重的血小板缺血症.
- 药物停用和支持性护理后对血小板计数的监测.
主要成果:
- 患者在开始使用trimethoprim-sulfamethoxazole后不久就出现了严重的血小板缺血症.
- 尽管药物戒断和支持性干预措施,血小板缺血仍然存在.
- 该患者最终因严重的血小板缺血的并发症而死亡.
结论:
- 在艾滋病患者中,三甲-硫甲醇可以加速危及生命的免疫性血小板缩.
- 免疫功能受损的状态可能会使DITP的呈现和管理变得复杂.
- 在给艾滋病患者开立trimethoprim-sulfamethoxazole时,仔细监测和考虑替代疗法至关重要.
相关概念视频
Secondary Active Transport
138.0K
One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme “pump” embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
138.0K
Secondary Active Transport
9.7K
One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme "pump" embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
9.7K
Secondary Healthcare System
2.1K
Secondary healthcare is offered by a specialist, generally in hospitals or clinics for patients referred by primary healthcare providers. It occurs when a person has an illness or injury that requires specific medical care. Secondary care is often referred to as acute care. Secondary care can range from uncomplicated care to repair a minor laceration or treat a strep throat infection to more complicated emergent care, such as treating a head injury sustained in an automobile accident. Whatever...
2.1K
What is the Immune System?
130.1K
Overview
130.1K
Primary and Secondary Growth in Roots and Shoots
60.6K
Vascular plants, which account for over 90% of the Earth’s vegetation, all undergo primary growth—which lengthens roots and shoots. Many land plants, notably woody plants, also undergo secondary growth—which thickens roots and shoots.
60.6K
Secondary Distribution
581
Secondary distribution systems provide electrical energy at the utilization voltage levels from distribution transformers to customer meters. Typical secondary voltages in the United States include 120/240 V for residential use, 208Y/120 V for residential and commercial use, and 480Y/277 V for industrial and high-rise commercial use.
In residential areas, 120/240 V single-phase, three-wire service is commonly used for lighting, outlets, and large appliances. Urban areas with high-density loads...
In residential areas, 120/240 V single-phase, three-wire service is commonly used for lighting, outlets, and large appliances. Urban areas with high-density loads...
581


