在与代谢功能障碍相关的脂肪性肝病中进行非侵入性肝纤维化评估
Tarsila C R Ribeiro1,2, Vitor de Paula Boechat Soares3, Julia Campos Fabri3
1Department of Medicine, Gastroenterology, University of Juiz de Fora School of Medicine, University Hospital of the Federal University of Juiz de Fora, Juiz de Fora 36021610, Minas Gerais, Brazil.
World journal of hepatology
|February 5, 2026
概括
非侵入性方法准确地评估了代谢功能障碍相关的脂肪性肝病 (MASLD) 中的肝纤维化. 这些工具有助于识别需要进一步评估的患者,减少侵入性肝脏活检的需要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 诊断成像 诊断成像 诊断成像
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 影响全球约32%的人口.
- 肝纤维化严重程度是MASLD临床结果的关键预测因素.
- 准确的纤维化评估对于管理MASLD患者至关重要.
研究的目的:
- 评估非侵入性方法 (NIMs) 的作用和诊断准确性,以评估MASLD中的肝纤维化.
- 为了比较NIM与传统肝脏活检的疗效.
- 确定NIM在MASLD患者风险分层中的有用性.
主要方法:
- 在主要数据库 (PubMed,Cochrane,SciELO,LILACS) 进行了系统的文献搜索.
- 关键词包括"代谢性脂肪性肝病"",非侵入性标志物"和"肝纤维化".
- 76篇相关文章被选中并被审查进行分析.
主要成果:
- 与肝脏活检相比,非侵入性方法提供了诸如简单性,可访问性和可重复性等优势.
- 尼姆可以实现成本效益高的风险分层,并可靠地排除晚期纤维化.
- 虽然中间纤维化阶段可能有局限性,但逐步的方法可以提高诊断的准确性.
结论:
- 非侵入性方法是评估MASLD肝纤维化的有价值的工具.
- 尼姆可以显著减少侵入性肝脏活检的需要.
- 结合NIM和临床判断,可以提高MASLD纤维化病期的诊断精度.
相关概念视频
Diseases of the Liver and Gallbladder
2.0K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
2.0K
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
202
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
202
Liver Histology
4.4K
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
Hepatocytes perform a variety of essential functions. They secrete...
4.4K
Liver Physiology
3.8K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
3.8K
Liver Regeneration
4.4K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.4K
Gross Anatomy of the Liver
2.1K
The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...
2.1K


