肠道屏障的损害,病毒的持久性和免疫失调在长期COVID中汇聚在神经系统的后续
Laurence Leclerc1,2, Johanne Poudrier1,2, Christopher Power3
1Center for Immunity, Inflammation and Infectious Diseases, Montreal Clinical Research Institute (IRCM), Montreal, QC, Canada.
Frontiers in aging neuroscience
|February 5, 2026
概括
长期COVID (LC) 是SARS-CoV-2感染后的复杂状况,涉及病毒持续性,免疫失调和肠道微生物组问题. 这些因素有助于神经炎症和神经系统疾病,建议新的治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
背景情况:
- 长期COVID (LC) 是一种多系统状况,在SARS-CoV-2感染后至少3个月被诊断出来.
- 关键症状包括疲劳,后炼症状恶化和神经精神问题.
- 现有的研究表明,复杂的,交叉的生物通路.
研究的目的:
- 综合关于长期COVID的潜在机制的证据.
- 提出一种用于LC病原发生的机械模型.
- 为了确定LC潜在的治疗策略.
主要方法:
- 系统审查和证据综合.
- 基于当前研究的机械建模.
- 确定参与LC的关键生物途径.
主要成果:
- 这种LC涉及病毒持久性,肠道失调,免疫激活 (NETs),血栓炎症和自身免疫.
- 这些过程破坏了血脑屏障 (BBB),导致神经炎症.
- 一个拟议的模型将抗原负载,微生物转位和炎症与中枢神经系统疾病联系起来.
结论:
- 长期COVID的发病因子是多因素的,涉及免疫,微生物和血管组成部分.
- 神经炎症和BBB功能障碍是LC的神经表现的核心.
- 针对抗原负载,肠道完整性和骨髓/凝固通路的治疗策略显示出有前途.
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