针对抑郁症的非侵入性横聚焦超声波对默认模式网络的影响:一个开放标签的试点试验
Jessica N Schachtner1, Jacob F Dahill-Fuchel1, Diheng Zhang1
1Psychology Department, Psychophysiology Lab, University of Arizona, Tucson, AZ, United States.
Frontiers in psychiatry
|February 5, 2026
概括
通过减少默认模式网络 (DMN) 超连接性,跨侧重超声波 (tFUS) 显示出治疗主要抑郁症 (MDD) 的前景. 这种神经调节技术降低了DMN连接性,为未来的临床试验提供了潜力.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗技术 医疗技术 医学技术
背景情况:
- 大型抑郁症 (MDD) 影响了20%的个人,经常复发,并且经常耐治疗.
- 异常的大脑连接,特别是默认模式网络 (DMN) 超连接,与抑郁症症状和重复的负面思想 (RNT) 有关.
- 跨焦超声波 (tFUS) 是一种新兴的神经调节技术,能够准特定的大脑网络.
研究的目的:
- 调查tFUS在减少MDD患者的DMN连接性的疗效.
- 探索DMN连接变化与抑郁症状和RNT变化之间的关系.
主要方法:
- 20名被诊断为MDD的参与者接受了多达11次tFUS会议,目标是左前中间前额叶皮质,这是一个关键的DMN枢纽.
- 休息状态功能磁共振成像 (fMRI) 和临床评估在tFUS治疗前后进行.
- 参与者完成了症状和不良事件的日常自我报告措施.
主要成果:
- 在tFUS治疗后,在左侧中间前额叶皮层和左后带带皮层之间观察到DMN连接的显著下降.
- 之前报告的抑郁症状和RNT显著减少.
- 探索性分析发现DMN连接的变化与抑郁症状或RNT的变化之间没有显著的相关性.
结论:
- 通过减少DMN超连接性,tFUS显示出作为MDD新型治疗的潜力.
- 观察到的DMN连接性下降,加上症状改善,支持在临床试验中进一步调查.
- tFUS提供了一种有针对性的神经调节方法,用于解决抑郁症背后的神经机制.
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