BCL-11使适应性应激反应能够应对环境挑战
Patrizia Niedworok1,2, Rossella Erminia Ciliberti1, Beijia Xie1
1German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany.
iScience
|February 5, 2026
概括
缺乏BCL-11会损害胰岛素/IGF-1信号传导 (IIS) 途径中的应激抵抗力,特别是影响Caenorhabditis elegans daf-2突变体. BCL-11对于增强成年动物的抗压能力至关重要.
科学领域:
- 细胞平衡是细胞的平衡.
- 代谢过程中的代谢.
- 抗压能力 抗压能力 抗压能力
背景情况:
- 胰岛素/IGF-1信号传导 (IIS) 是新陈代谢和应激反应的关键调节者.
- 在C. elegans中,DAF-2和DAF-16/FOXO是IIS的核心组成部分.
- BCL-11是一种与人类神经发育障碍相关的进化保守的转录因子.
研究的目的:
- 研究BCL-11在IIS通路中的作用.
- 确定病原性BCL-11变种如何影响C. elegans的发育和应激反应.
- 在IIS缺乏的动物中阐明BCL-11和DAF-16之间的相互作用.
主要方法:
- 使用Caenorhabditis elegans作为一个模型生物.
- 生成并分析了低形态bcl-11突变.
- 在标准和压力条件下评估bcl-11缺乏对daf-2信号传递的影响.
- 检查了卵化缺陷和转录相互作用使用DAF-16功能丧失.
主要成果:
- 在正常情况下,低形态bcl-11突变对C. elegans的生长和生存的影响很小.
- 缺乏BCL-11损害了daf-2信号传递的压力保护功能.
- 在daf-2;bcl-11突变体中,daf-16的丧失挽救了胚胎致死性,这表明了转录相互作用.
- BCL-11在发育和应激反应期间的转录调节中发挥作用.
结论:
- 在发育过程中,BCL-11积极调节转录.
- 在成年动物中,BCL-11在环境侮辱时被招募,以增强应激弹性.
- BCL-11是IIS介导的应力适应的关键调节器.
更多相关视频
相关概念视频
Responses to Heat and Cold Stress
14.8K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
14.8K
Responses to Salt Stress
14.6K
Salt stress—which can be triggered by high salt concentrations in a plant’s environment—can significantly affect plant growth and crop production by influencing photosynthesis and the absorption of water and nutrients.
14.6K
Stress Response System
906
The stress response system, also known as the fight-or-flight response, is the body's automatic physiological reaction to perceived threats. Hans Selye introduced the concept of General Adaptation Syndrome (GAS) to describe the predictable pattern of changes that occur in response to stress. GAS consists of three sequential stages: alarm, resistance, and exhaustion. This model helps explain how chronic stress can contribute to health problems.
Alarm stage
In the alarm stage, the body's...
Alarm stage
In the alarm stage, the body's...
906
Cells of the Adaptive Immune Response
8.9K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
8.9K
Psychological Responses to Stress
715
Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
715
Other Stress Responses in Bacteria
408
Bacteria have global regulatory systems that control several types of stress mechanisms. These include Pho regulon and the heat shock response, which are essential systems for environmental adaptation, such as nutrient limitation and proteotoxic stress. The Pho regulon and the heat shock response exemplify bacterial resilience, enabling rapid adaptation to fluctuating environmental conditions.Pho RegulonBacteria require phosphorus for essential cellular processes, including nucleic acid...
408


