肺大细胞神经内分泌癌与大脑转移的异常长期存活:一个病例报告
Bin Liu1, Liangwen Zhang1, Hua Wang2
1Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Frontiers in oncology
|February 5, 2026
概括
在脑转移的高级大细胞神经内分泌癌 (LCNEC) 中,长期存活是罕见的,但可以实现的. 这一案例突显了个性化多式疗法和生物标志物监测在延长转移性LCNEC患者的存活时间方面的成功.
科学领域:
- 在瘤学瘤学.
- 神经科学是一个神经科学.
背景情况:
- 肺部的大细胞神经内分泌癌 (LCNEC) 是一种罕见的,具有不良预后的侵袭性癌症,特别是在脑转移的晚期阶段.
- 对于转移性LCNEC存在有限的治疗选择,这使得长期存活非常罕见.
研究的目的:
- 报告一个独特的长期存活病例,该病例发生在患有第四期肺LCNEC和大脑转移的患者身上.
- 突出综合多模式治疗方法和纵向监测的有效性.
主要方法:
- 一名患有第四期肺性LCNEC的32岁女性接受了化疗,向治疗,手术 (切,骨盆转移切除) 和全脑放射治疗.
- 纵向监测包括连续成像和前胃释放 (PRO-GRP) 水平跟踪.
- 进行了分子分析,以确定潜在的治疗点.
主要成果:
- 患者在10年的疾病过程中实现了肺病变的长期稳定性和大脑转移的动态控制.
- PRO-GRP水平与瘤进展有很强的相关性.
- 患者在诊断后的115个月和最初的大脑转移诊断后的50个月内仍然活着.
结论:
- 这一案例表明,通过个性化多式疗法和密切监测,在LCNEC第四期脑转移中延长存活是可能的.
- 分子分析和PRO-GRP等生物标志物可能在LCNEC的治疗规划和疾病管理中发挥关键作用.
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