额叶脑电图不对称性与精神分裂症认知预后的相关性
1Department of Psychiatry, Ningbo Psychiatric Hospital, Ningbo 315032, Zhejiang Province, China.
World journal of psychiatry
|February 5, 2026
概括
前脑电图 (EEG) 的不对称性,特别是当眼睛打开时,以及前脑双眼网络 (FPN) 连接性与精神分裂症患者的认知结果有关. 这些发现为精神分裂症认知缺陷的神经生物学提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 精神分裂症的特点是影响功能结果的认知障碍.
- 这些缺陷的神经生物学基础,特别是前脑电图 (EEG) 不对称性,需要进一步研究.
- 了解EEG不对称性对于预测精神分裂症的认知预后至关重要.
研究的目的:
- 调查前额叶EEG不对称性和精神分裂症患者的认知预后之间的关联.
- 探索前端对象网络 (FPN) 连接和认知结果之间的关系.
主要方法:
- 在2020-2023年期间治疗的104名精神分裂症患者的回顾性分析.
- 根据共识认知电池得分的共识认知预后分为好和坏的认知预后组.
- 通过静止状态fMRI评估正面EEG不对称性 (眼睛打开和眼睛关闭) 和FPN连接.
主要成果:
- 在开眼前脑电图不对称和认知结果之间发现了显著的相关性 (P=0.0482,P=0.0111).
- 左和右FPN连接与认知预后不佳负相关 (P=0.015,P=0.008).
- 两组之间没有观察到横向性指数的显著差异.
结论:
- 眼睛开放的正面EEG不对称性与精神分裂症的认知预后有关.
- 前端对象网络 (FPN) 连接性也显示出与认知结果的显著关系.
- 这些神经生理学标记可以作为精神分裂症认知功能的预测剂.
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