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来自海洋菌的多功能Se-Cu双金属纳米颗粒:向氧化应激,炎症和微生物生物膜
Anes A Al-Sharqi1, Mohamed E Eissa2, Dareen Alyousfi3
1Photonics Unit, Institute of Laser for Postgraduate Studies, University of Baghdad Al-Jadiriah, P.O.Box 47314 Baghdad Iraq anes@ilps.uobaghdad.edu.iq.
RSC advances
|February 5, 2026
概括
海洋细菌被用来合成具有显著抗氧化,抗炎和抗菌特性的-铜双金属纳米颗粒 (Se-Cu BMNPs). 这些生物相容纳米颗粒显示出各种生物医学应用的前景.
科学领域:
- 纳米技术和材料科学 材料科学
- 生物技术和微生物学
- 药理学和治疗学 药理学和治疗学
背景情况:
- 开发具有多种生物活性的新型纳米材料对于推进生物医学应用至关重要.
- 海洋微生物为纳米粒子合成提供了生物活性化合物和生物合成途径的独特来源.
- -铜双金属纳米粒子 (Se-Cu BMNPs) 由于其构成元素的协同特性而引起人们的兴趣.
研究的目的:
- 使用海洋细菌Bacillus licheniformis LHG166.6的代谢提取物合成Se-Cu BMNP.
- 描述合成的Se-Cu BMNP并评估它们的抗氧化,抗炎,抗微生物和抗菌膜活动.
- 评估这些生物相容的Se-Cu BMNP在生物医学应用中的潜力.
主要方法:
- 使用细菌代谢提取物进行Se-Cu BMNP的生物合成.
- 使用UV-Vis光谱,FT-IR,XRD,TEM,EDX和DLS进行表征.
- 在体外评估抗氧化剂 (DPPH,ABTS),抗炎药物 (COX-1,COX-2抑制),抗微生物 (井扩散,汁微稀释) 和抗菌膜测定.
主要成果:
- 已经成功合成了具有球形形态 (20-120 nm) 和Cu:Se原子比率约为1:1的Se-CuBMNP.
- 这些纳米粒子表现出强大的抗氧化活性 (DPPH清除高达96.1%,ABTS高达94.6%),显著的抗炎作用 (COX-1抑制高达97.3%,COX-2高达95.3%),以及针对测试的细菌和真菌的广泛抗菌活性.
- 观察到有效的生物膜形成抑制,在最低杀菌/杀菌度的75%下,对几种微生物的90%以上的抑制.
结论:
- 海洋细菌代谢物促进生物相容的Se-Cu BMNP的绿色合成.
- 合成的Se-Cu BMNP具有显著的抗氧化,抗炎,抗微生物和抗菌膜特性.
- 这些发现突出了Se-Cu BMNP来自Bacillus licheniformis的潜力,用于各种生物医学应用.
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