精神分裂症谱系障碍中的视网膜生物标志物:神经发育和神经退行性模型的证据和影响
Brittany A Blose1,2, Steven M Silverstein2,3,4
1Department of Psychology, University of Rochester, Rochester, NY, United States.
Frontiers in medicine
|February 5, 2026
概括
精神分裂症中的视网膜异常可能反映神经发育,而不仅仅是神经退行性,过程. 本综述整合了整个生命周期的发现,以了解大脑功能障碍和指导干预.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 精神病学是一个精神病学.
背景情况:
- 精神分裂症与视网膜变化有关,通常被视为神经退行性.
- 这些视网膜变化的神经发育方面仍未得到充分探索.
- 现有的研究缺乏一个整合不同疾病阶段的寿命视角.
研究的目的:
- 在精神分裂症中组织视网膜异常的证据,跨疾病阶段 (CHR,FEP,慢性).
- 在精神分裂症病理生理学上整合神经发育和神经退行性观点.
- 提出一个寿命模型,以了解精神分裂症中视网膜变化.
主要方法:
- 对精神分裂症视网膜变化的研究进行系统审查.
- 包括来自临床高危精神病,遗传风险,第一发精神病和慢性精神分裂症样本的数据.
- 考虑产前/产周侮辱,神经发育障碍和神经软体征的相关发现.
主要成果:
- 视网膜变化存在于精神分裂症谱中,从高风险状态到慢性疾病.
- 证据表明神经发育和神经退行性对视网膜变化的贡献.
- 寿命数据可以为了解精神分裂症中中枢神经系统差异提供信息.
结论:
- 精神分裂症中的视网膜变化提供了一个"进入大脑的窗口",反映了神经发育轨迹.
- 整合神经发育和神经退行性因素的寿命模型至关重要.
- 了解这些轨迹可以改善精神分裂症的诊断,监测和治疗.
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