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Updated: Feb 6, 2026

Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity
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Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity

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佩奥尼佛林通过通过TLR4/NF-κB通路重新编程巨细胞极化来减轻败血症引起的肝损伤

Zhiwei Rong1,2, Baitian Li3, Chunzheng Liu2

  • 1Postgraduate Training Base of Jinzhou Medical University, Shanghai East Hospital, Shanghai, China.

Frontiers in immunology
|February 5, 2026
PubMed
概括

佩奥尼佛洛林通过转移巨细胞两极分化并抑制TLR4/NF-κB通路来防止败血症相关的肝损伤 (SALI). 这种天然化合物显示出作为SALI的新型免疫调节疗法的希望.

关键词:
通过TLR4/NF-κB途径.肝脏保护 肝脏保护巨细胞的两极分化佩奥尼弗洛林是一种.与败血症相关的肝损伤

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