相关实验视频
Updated: Feb 6, 2026

07:22
Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
9.5K
过敏原提取物在儿科队列中的基细胞激活测试中表现优于分子成分
Alexandre Chhing1, Simone Choi1,2, Dounia Khelifi-Touhami1
1Immunology Department, St-Antoine & Trousseau Hospital, Sorbonne University, AP-HP, Paris, France.
Frontiers in immunology
|February 5, 2026
概括
在过敏测试中,分子过敏原的激活基细胞的能力低于提取物. 基于提取物的基激活测试 (BAT) 通常是首选的,特别是在牛奶中,以避免假阴性结果.
科学领域:
- 过敏原免疫疗法免疫疗法
- 免疫学 免疫学 免疫学
- 分子诊断学 分子诊断学
背景情况:
- 分子过敏原在过敏诊断中增强特定的IgE血清学.
- 在基激活试验 (BAT) 中分子过敏原的附加值尚不清楚.
研究的目的:
- 评估使用分子过敏原与源提取物对 BAT 的一致性.
- 为了确定导致BAT异常的因素,提取物和分子组件之间的差异.
主要方法:
- 用分子成分和相应的提取物进行的BAT的回顾性分析.
- 分析了各种过敏原的213种可解释的BAT提取物/成分对的数据.
主要成果:
- 在提取物和组件的BAT结果之间观察到适度一致 (κ = 0.62).
- 18%的BAT对显示出不一致的结果,其中提取物+/成分-更频繁 (69%) 并表明真正的过敏.
- 与提取物刺激基因细胞相比,成分刺激基因细胞的激活率较低 (6%低),即使在一致的情况下也是如此.
结论:
- 分子成分表现出比提取物激活IgE敏感基因细胞的能力较低.
- 基于组件的BAT可能导致错误的负结果;基于提取物的BAT通常是推的,特别是对于牛奶.
- 诸如总IgE和免疫疗法等因素可以影响BAT不一致性.
相关概念视频
Components of Stress
543
Stress analysis under multiple loading conditions is intricate, necessitating a comprehensive grasp of normal and shearing stresses. Consider a small cube at point O, subjected to stress on all six faces, visible or not. Normal stress components σx, σy, σz act perpendicularly to the x, y, and z axes. Shearing stress components τxy and τxz are exerted on faces perpendicular to these axes.
Interestingly, the hidden cube faces also experience these stresses, equal and...
Interestingly, the hidden cube faces also experience these stresses, equal and...
543
Components of Language
821
Language, whether spoken, signed, or written, consists of specific components: lexicon and grammar. The lexicon is the vocabulary of a language, comprising its words. Grammar is the set of rules used to convey meaning through the lexicon. For example, English grammar adds “-ed” to most verbs to indicate past tense. Words are formed by combining phonemes, which are the basic sound units of a language. Different languages have different sets of phonemes (e.g., “ah” vs.
821
Molecular Models
43.8K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
43.8K
Allergic Reactions
32.4K
Overview
32.4K
Pharmacokinetics in Pediatric Patients: Drug Excretion
266
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
266
Molecular Orbital Theory II
27.5K
Molecular Orbital Energy Diagrams
27.5K

