患有多发性内分泌新陈代谢1型患者中的胰岛素耐药性:系统性审查和元分析
Berk Celik1, Leticia De Mattei1, Julia Meireles1
1Department of Internal Medicine, Corewell Health William Beaumont University Hospital, Royal Oak, Michigan.
AACE endocrinology and diabetes
|February 5, 2026
概括
患有多发性内分泌新陈代谢1型 (MEN1) 的患者具有显著更高的胰岛素抗性. 在MEN1患者中早期查葡萄糖耐受性损害可以预防心血管事件并改善预期寿命.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 遗传学 是一个遗传学.
背景情况:
- 多发性内分泌瘤瘤1型 (MEN1) 是一种遗传性疾病,使个体易患内分泌腺瘤.
- 之前的研究表明,MEN1患者的胰岛素耐药性,心血管疾病和寿命缩短的比率更高.
- 在MEN1中胰岛素抵抗的确切程度需要进一步调查.
研究的目的:
- 进行元分析,以评估患有MEN1的个体中胰岛素抵抗的患病率.
- 量化MEN1与胰岛素抵抗之间的关联.
主要方法:
- 在主要科学数据库 (PubMed,Embase,Scopus,Web of Science,CENTRAL) 的系统文献搜索.
- 纳入标准:包括至少5名MEN1患者报告胰岛素耐药性的研究.
- 使用随机效应模型进行元分析,以计算胰岛素抵抗患病率的几率比率.
主要成果:
- 五项涉及606名MEN1患者和4431名对照者的研究符合纳入标准.
- 在MEN1患者中,胰岛素抵抗的患病率显著增加 (OR=5.58;95%CI [4.02,7.74]).
- 研究之间没有观察到显著的异质性 (Tau2 = 0,P = 0.4552),这证实了强有力的发现.
结论:
- 这是第一个表现出与对照组相比,MEN1患者胰岛素耐药性患病率显著更高的元分析.
- 在MEN1中,胰岛素抵抗的风险增加与年龄,性别或BMI无关.
- 建议在MEN1患者中早期查葡萄糖耐受性受损,以减轻心血管风险并提高寿命.
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