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相关概念视频

Stereoisomerism of Cyclic Compounds02:33

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In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...
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Cyclic voltammetry (CV) is an electrochemical technique used to investigate the redox properties of a chemical species. It involves measuring the current response of an electrochemical cell as a function of the applied potential. The setup for cyclic voltammetry typically consists of a working electrode, a reference electrode, and a counter electrode—all immersed in an electrolyte solution. The working electrode is where the redox reaction of interest occurs, while the reference electrode...
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A thermodynamic system with zero heat exchange and work is an isolated system. For these systems, the internal energy remains constant.
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Updated: Feb 6, 2026

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
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对于周期性库希病的奥西洛德罗斯塔特.

Jane Rhyu1, Run Yu1

  • 1Division of Endocrinology, Diabetes, and Metabolism, University of California, Los Angeles (UCLA) David Geffen School of Medicine, Los Angeles, California.

AACE endocrinology and diabetes
|February 5, 2026
PubMed
概括
此摘要是机器生成的。

周期性库希综合征是一种罕见的疾病,可以通过osilodrostat有效管理. 这种药物表现出快速,可逆抑制高皮质醇症,突出其治疗这种具有挑战性的内分泌疾病的潜力.

关键词:
循环的 库希氏病 循环的 库希氏病周期性的库希综合征 库希综合征旋转的状态 旋转的状态

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相关实验视频

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科学领域:

  • 内分泌学 在内分泌学.
  • 内部医学 内部医学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 循环库希综合征是一种罕见的内分泌疾病,其特点是间歇性高皮质醇症和自发缓解.
  • 过高皮质醇症带来严重的死亡风险,并与许多并发症有关,需要及时有效的管理.

研究的目的:

  • 报道了第一个已知的使用osilodrostat治疗本地循环库希综合征.
  • 为了评估osilodrostat在患有周期性库辛综合征的患者的疗效,可逆性和对上腺功能的影响.

主要方法:

  • 一名68岁的男性患者患有复发性周期性库希综合征,接受了osilodrostat的治疗.
  • 监测临床症状,实验室值 (尿液自由皮质醇,ACTH,血清皮质醇,) 和垂体成像.
  • 评估了患者对奥西洛德罗斯塔特的反应,包括上腺功能不全的发展和可逆性.

主要成果:

  • 奥西洛德罗斯塔特治疗导致实验室值和临床症状在2-3周内显著改善.
  • 患者在剂量定位后经历了药物诱导的可逆上腺功能不全.
  • 在停止治疗后,患者实现了临床缓解,证实了药物的可逆性.

结论:

  • 奥西洛德罗斯塔特是循环库希综合征的有效治疗方法,可快速和可逆地抑制高皮质醇症.
  • 这一案例突出显示了osilodrostat在管理高皮质醇症的能力,同时保持正常的上腺功能,这对于循环呈现至关重要.
  • 奥西洛德洛斯塔特是周期性库希综合征的一种有前途的治疗选择,特别是当手术治疗不可能时.