对的安全性进行比较:与竞争的酸阻塞剂与质子抑制剂
Minyoung Jang1, Sungmi Kim1,2, Minhyung Kim1
1Division of Nephrology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Clinical kidney journal
|February 5, 2026
概括
与质子抑制剂 (PPI) 相比,竞争性酸阻断剂 (P-CABs) 显示功能下降的风险较低. 这表明P-CABs可能为长期管理酸性抑制提供更安全的替代方案.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 质子抑制剂 (PPI) 与急性损伤和慢性病的风险增加有关.
- 竞争性酸阻断剂 (P-CABs) 的效应, PPI的新兴替代品,需要进一步调查.
研究的目的:
- 在接受酸抑制治疗的患者中,比较P-CAB和PPI之间的结局.
- 评估P-CABs关于脏功能的安全概况.
主要方法:
- 在2019年至2023年期间,在韩国的第三级转诊医院进行了一项比较研究.
- 脏结局包括肌素的翻倍和估计的淋巴细胞过率 (eGFR) 的≥50%下降.
- 考克斯的比例危险分析被用来调整多个共同变量.
主要成果:
- 与PPI组 (5,121名患者) 相比,P-CAB组 (1820名患者) 的肌素翻倍和eGFR下降发生率明显较低.
- 使用P-CAB与共同变量调整后,肌素翻倍 (HR 0.52;P < .001) 和EGFR下降 (HR 0.63;P = .005) 的危险比率降低有关.
- 在P-CAB组,每1000人年发生率为肌素翻倍的13.4和EGFR下降的18.4,而在PPI组分别为36.5和39.
结论:
- 与PPI相比,P-CAB似乎与较低的功能下降风险有关.
- 这些发现表明,P-CABs可能是需要长期抑制酸的患者更安全的替代品.
- 需要进一步研究涉及多种P-CAB和PPI,以证实这些脏安全研究结果.
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