与病理完整反应相关的风险因素及其对HER2-低乳腺癌患者结果的影响:倾向性得分匹配研究
1Department of General Surgery, The Second Affiliated Hospital of Jiujiang College, 1699 Shili Avenue, Jiujiang, 332005 China.
Indian journal of surgical oncology
|February 5, 2026
概括
针对低HER2乳腺癌的新辅助化疗 (NAC) 显示了诸如阶段和Ki-67等因素对病理完整反应 (pCR) 的影响. 实现pCR可以减少复发,但对整体存活率的影响有限.
科学领域:
- 在瘤学瘤学.
- 乳腺癌研究研究 乳腺癌研究
- 化疗疗的有效性 化疗的有效性
背景情况:
- 对于HER2低乳腺癌的新辅助化疗 (NAC) 存在有限的临床试验.
- 影响NAC疗效的因素及其在该人群中的预后影响尚不清楚.
- 了解病理完整反应 (pCR) 的预测因素对于治疗优化至关重要.
研究的目的:
- 在接受NAC的HER2-低乳腺癌患者中探索与pCR相关的风险因素.
- 调查pCR对无病生存期 (DFS) 和整体生存期 (OS) 的预后影响.
- 确定pCR,DFS和OS的独立预测和影响因素.
主要方法:
- 对510名接受NAC.低HER2乳腺癌患者的回顾性分析.
- 从医疗记录收集的关于临床治疗和随访的数据 (2018年2月 - 2022年2月).
- 进行了倾向性得分匹配和考克斯比例危险回归分析.
主要成果:
- 对于pCR的独立预测因素包括临床阶段 (cStage),激素受体 (HR) 状态,Ki-67,诺丁汉瘤阶段和内分泌治疗.
- 实现pCR与改善的DFS显著相关 (70.0%与87.5%相比).
- 虽然pCR显示了改善OS的趋势 (85.0%与88.8%相比),但这种差异在统计学上并不显著. c阶段,HR状态和内分泌疗法独立地影响了DFS和OS.
结论:
- 临床阶段,HR状态,Ki-67,诺丁汉瘤阶段和内分泌疗法与HER2-低乳腺癌的PCR成就有显著的相关性.
- pCR与复发风险降低 (改善DFS) 有关.
- 在接受NAC的HER2-低乳腺癌患者中实现pCR的生存益处似乎有限.
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